Brazytė, Laura

Background and Objectives Cervical cancer (CC) is the fourth most diagnosed cancer and the fourth leading cause of cancer related deaths, according to WHO. In 2020, approximately 604 000 new cases and 342 000 of deaths caused by cervical cancer were determined. According to the cancer registry (2017), CC was the sixth most frequently diagnosed cancer in women and the eighth cause of death from cancer in Lithuania. Genetic biomarkers are frequently encountered in the study of the development, course, and outcome of various tumors. Studies have shown that SULT1A1 and UGT1A1 genes are associated with an increased risk of developing cancer. It is known that SULT1A1 and UGT1A1 polymorphisms can determine changes in estrogen metabolism and lead to the formation of cervical cancer. However, the role of these genes and their polymorphisms on cervical cancer has not been well studied yet. Therefore, the aim of this study was to investigate SULT1A1 rs1042028 and UGT1A1 rs5839491 polymorphisms and determine their relationship with the clinical and morphological features of cervical cancer and the course of the disease in cervical cancer patients. [...]. Conclusions and Recommendations In this study statistically significant associations were found between SULT1A1 and the degree of tumor differentiation (G), UGT1A1 and age at the time of diagnosis. No statistically significant association with survival and time to progression was found. Therefore, studies with a larger sample should be performed in order to more accurately assess the influence of these genes and their polymorphisms in patients with CC.