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Naphthoquinones exert cytotoxic and anti-proliferative effects on Glioblastoma multiforme C6 culture cells / Aiste Palukaityte, Daiva Majiene
Type of publication
Recenzuojamos iÅ¡plÄstinÄs tezÄs / Peer-reviewed extended theses (T1d)
Title
Naphthoquinones exert cytotoxic and anti-proliferative effects on Glioblastoma multiforme C6 culture cells / Aiste Palukaityte, Daiva Majiene
Publisher (trusted)
Faculty of Pharmacy of Lithuanian university of Health Sciences
Date Issued
2015-11-05
Extent
p. 59-59.
Is part of
The 6th International Pharmaceutical Conference Science and Practice 2015 : book of abstracts : November 5-6, 2015, Kaunas, Lithuania / Faculty of Pharmacy of Lithuanian university of Health Sciences. LSMU FF Alumni association. Lithuanian Pharmaceutical association. Lithuanian Pharmacists' Society. Kaunas : Lithuanian university of Health Sciences, 2015. ISBN 9789955154105.
Version
Originalus / Original
Series/Report no.
Poster session.
Description
ISBN 978-9955-15-410-5.
Bibliogr.: p. 59
Field of Science
Abstract
Glioblastoma multiforme tumor (GMB) is the highest grade glial tumor and most common in the astrocytic line, causing approximately 50% of all glial tumors. GMB could be treated by surgery, radiation or chemotherapy, but median survival is 9 to 14 months with a 5-year survival rate approximately 3%. Bioactive compounds could be used to increase cancer cell sensitivity to chemotherapy. Naphthoquinones are compounds extensively used in studies due to their role in plants as chemicals for defense. Studies have shown that naphthoquinones such as menadione, plumbagin and lawsone have anti-cancer effects on GMB. The aim of this study is to investigate and compare the results between different concentrations of plumbagin, menadione and lawsone effectiveness on rat glioblastoma cell culture C6 viability, and assess their impact to the GBM cell proliferation. Methods: Cell viability was assessed by measuring their ability to metabolize MTT. [...].
Type of document
type::text::conference output::conference proceedings::conference paper
ISBN (of the container)
9789955154105
Other Identifier(s)
(LSMU ALMA)990000881880107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Bibliographic Details
5