GABA PAM drugs effect on the Oppel-Kundt illusion visual processing for people with schizophrenia spectrum disorders
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2017-12-01 |
eISSN 1648-9144.
Background and Aim: A dysfunctional visual processing, visual stimulus integration and GABAergic dysfunction were found among patients with schizophrenia spectrum disorders (SSD). Better understanding of GABA positive allosteric modulators (PAM) effect on the Oppel-Kundt illusion manifestation for patients with SSD is needed to get insight in illusion genesis and visual dysfunction among people with SSD. Materials and Methods: Subject and control group were patients from Hospital of Lithuanian University of Health Sciences (LUHS), Kaunas Clinics. Study protocol was approved by LUHS Bioethics Center. Exclusion criteria were any impairment causing inability to perform a test. The stimuli: white spots were presented horizontally against a black background according to the Oppel-Kundt pattern. Using computerized equipment, the subjects adjusted the unfilled part of the stimulus to be equal in length to the referential one. The number of the filling spots in the referential interval varied from 0 to 19. Each subject repeated experiments 10 times. GABA PAM prescriptions gathered from medical records. ANOVA, Bonferroni post-hoc test and T-test were used for statistical analysis. Results: Study group: 30 persons with SSD and 25 matched individuals. During 170 of experiments patients involved in the study were on various GABA PAM. There were 130 experiments when patients were not on GABA PAM. Patients who were on GABA PAM during the experiment have made smaller errors than patients who were not on GABA PAM when presented from 1 to 18 referential interval filling spots, difference of the errors between two groups varied from 2,87 to 4,6 arc min. Patients who were on GABA PAM during the experiment have made notably larger errors than comparison group when referential line was filled with 0, 3, 9–14,19 spots. Conclusions: The Oppel-Kundt illusion tended to manifest weaker for patients with SSD, but stronger for those who recei[...].