Association between sexual health and quantity of androgen receptor CAG polymorphism in combined oral contraceptive users
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2016-05-04 |
(AR) gene polymorphism. Second, we wanted to determine the link between sexual health changes and combined oral contraceptive (COCP) usage, and third, we aimed to determine the association between sexual function changes and AR gene polymorphism in COCP users. Methods: A randomised case-control study took place during the period from February 2013 to February 2014. The study included 98 healthy 18–40-year-old women with regular menstrual cycles (25–35 days), who were consulted for the usage of contraception. The control group (n¼40) consisted of women, using barrier contraception or natural family planning methods. The study group (n¼58) was composed of women using COCP (ethinylestradiol 0.03 mg/drospirenone 3 mg). The Female Sexual Function Index (FSFI) questionnaire was implemented to evaluate women sexual function. Women were asked to fill out the FSFI in the beginning of the study and after six months. Results: Homozygote women with short-short (SS) alleles were dominant in both groups: 50.7% (n¼30) for the control group and 56.0% (n¼22) for the study group. The average count of homozygote women with long-long (LL) alleles was found to be, respectively, 30.7% (n¼23) and 29.0% (n¼12). The lowest number of heterozygote women with short-long (SL) alleles was discovered in the study population: 18.6% (n¼14) for the study group and 15.0% (n¼6) for the control group. FSFI showed risk for sexual dysfunction (FSFI 26.55) for more than half the patients in the study group (55.2%; n¼32) and for one third of women in the control group (30.0%; n¼12). After evaluating FSFI subscales, it was detected that women in the study group were significantly more likely to experience pain during sexual intercourse if compared to the control group (p¼0.01). Sexual arousal, lubrication, orgasm, satisfaction scores did not differ significantly between the groups respectively (p¼0.6; p¼0.4; p¼0.5; p¼0.3). There was[...].