Investigation of Polymorphism rs8819 in the SRSF1 Gene: Implications for Pathomorphological Characteristics in Cervical Cancer and Disease Progression

Abstract

Background and Objectives Cervical cancer stands among the most commonly diagnosed cancers and is the leading cause of cancer-related mortality among women globally. SRSF1, or serine and arginine rich splicing factor 1, stands as a pivotal proto-oncogene frequently elevated in cancer. Within the SR protein family, it governs splicing regulation alongside other pivotal RNA metabolic processes such as mRNA stability, nuclear export, and miRNA processing. Its upregulation is a common occurrence across various cancer types, often associated with genomic instability and cellular transformation. Elevated levels of SRSF1 have been observed in prostate, lung, breast, colon, cervical and glioblastoma cancers. This overexpression has been linked to various mechanisms within cellular pathways, amplifying its oncogenic role in tumorigenesis and disease progression. There are very limited data about Single Nucleotide Polymorphisms (SNPs) in SRSF1 and cancers. Objective To assess the correlations between genetic variants of rs8819 in the SRSF1 gene influencing tumor characteristics and the course of cervical cancer. [...].