In vitro antibacterial activity of polymeric materials and diclofenac sodium

Abstract

Vision is a primary sense that provides a distinct survival advantage to most animals. Topical ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in veterinary medicine to control chronic or acute low-grade ocular inflammation, such as anterior uveitis and corneal epithelial lesions, and to reduce postoperative inflammation to prevent postoperative miosis during cataract surgery. NSAIDs used in ophthalmology include topical derivatives of salicylic acid, indole acetic acid, aryl acetic acid, aryl propionic acid, and enolic acid. The diclofenac sodium selected in this study inhibits prostaglandin synthesis in the body. When an inflammatory process occurs, the phospholipids of cell membranes, with the participation of the enzyme phospholipase A, produce arachidonic acid, which with the help of the enzymes cyclooxygenases (COX) 1 and (COX) 2 turns into prostaglandin G2, from which other prostaglandins and thromboxane are subsequently produced. Thus, diclofenac sodium inhibits COX 1 and COX 2 enzymes, as a result of which prostaglandin synthesis is inhibited. [...].