Insight into cell communication: from apoptotic bodies down to exomeres : [tarptautinis pranešimas]

Abstract

The extracellular vesicle and particle research field exploded with new data over the recent decade, erasing the barriers between the different extracellular vesicle classes and extending the size range of these intercellular communicators up and down from nearly cell-sized apoptotic blebs to several nanometer particles. Exosomes, microvesicles, migrasomes, oncosomes, mitovesicles, exomeres, chromatimeres are smurfing from cell to cell, travelling large distances, ignoring biological barriers and exchanging intracellular material all over the body, between the gut, the airway, the brain and the heart. In this talk, we will overview the role of different extracellular vesicles and particles in physiology and pathology, with a specific focus on vesicular communication between the airway and the brain during viral infections, vesicular crosstalk in the tumour microenvironment and beyond, involvement of extracellular vesicles in neurodegeneration and current trends in cell-derived vesicle application.