Antimicrobial susceptibility pattern of H. pylori strains isolated from adult dyspeptic patients in Latvia

Abstract

Introduction: To make a choice for the best therapeutic strategy for H. pylori (Hp) eradication the local knowledge of resistance pattern is necessary. However, there is lack of information on the antimicrobial susceptibility pattern of Hp in Latvia. Aim: To determine the current state of metronidazole, clarithromycin and tetracycline primary resistance in Hp clinical isolates. Patients and Methods: In total 173 Hp strains (142 - from antrum, 31 - from corpus) from 146 patients referred for upper endoscopy due to dyspeptic problems were analysed. Patients with gastric cancer, peptic ulcer, previous gastric surgery or eradication therapy were excluded. Antibacterial susceptibility to metronidazole (MTR), clarithromycin (CLR) and tetracycline (TCY) was determined by disk diffusion and E-test methods. Results: The resistance rates were 47,6% for metronidazole, 2,7% for clarithromycin and 1,4% for tetracycline. Single antimicrobial resistance was found in 61(42%) and double - in 5(3%) patients. In 12 patients (8,2%) co-infection by two strains with different resistance pattern was detected. 5 antibiotypes were revealed (table). [...].