Time-of-Flight Secondary Ion Mass Spectrometry bio-imaging analysis of soy-bean oil fatty acids skin penetration
Author(s) | |
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Elie, Nicolas | Institut de Chimie des Substances Naturelles, Université Paris-Sud, France |
Brunelle, Alain | Institut de Chimie des Substances Naturelles, Université Paris-Sud, France |
Other(s) | ||
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Duodantis interviu / Interviewee |
Date Issued |
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2015-11-05 |
ISBN 978-9955-15-410-5.
Bibliogr.: p. 21
Introduction. The topical use of natural oils has been increasing each year and their effects on human health are being debated as controversial. Changes in skin barrier permeability profiles after application of fatty acids found in natural oils have been demonstrated. Current study is a continuum of previous research, when the effect of fatty acids to enhance tolnaftate dermal penetration has been evaluated, and a biological imaging Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) technique has been applied (1,2)linoleic, lauric and capric acids into human skin was studied by Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS. The same technique was applied to study penetration of palmitoleic, palmitic, linoleic, oleic, and stearic fatty acids into the skin alone and from soybean oil - which is now being used for various health promoting effects. Excessive human skin was used in the penetration studies. Linoleic, oleic, palmitoleic, palmitic and stearic fatty acids 10% (w/w) solutions in PEG 400 and pure soybean oil were applied on the skin. The experiments were performed using Bronaugh-type flow-though diffusion cells for 6 h. A commercial TOF-SIMS IV mass spectrometer was used for sample analysis (1)linoleic, lauric and capric acids into human skin was studied by time-of-flight secondary ion mass spectrometry (TOF-SIMS. [...].