Use this url to cite publication: https://hdl.handle.net/20.500.12512/48503
Histamine releasing action of calcium ionophore 985-I
Type of publication
Straipsnis kitoje duomenų bazėje / Article in other database (S4)
Author(s)
| Author | Affiliation |
|---|---|
Gushchin, Igor S. | |
Title
Histamine releasing action of calcium ionophore 985-I
I.S. Gushchin, A.I. Zebrev, V.G. Voitenko
Extent
p. 161-164.
Is part of
Agents and actions. , 1988, vol. 23, no. 3-4.
Version
Originalus / Original
Abstract (en)
The polyether antibiotic 985-I induced histamine release from rat and mouse mast cells and human basophils. Histamine release induced by low concentrations (10-50 microM) of the ionophore was a selective (noncytotoxic) process. It was energy and Ca2+-dependent and was potentiated by glucose. In this respect the mode of action of 985-I was similar to that of the Ca2+-ionophore A23187. On the other hand some pharmacological agents (phencarol, verapamil and amitriptyline) inhibited histamine secretion induced by 985-I but not A23187-induced histamine release. These data point to some differences between the mechanisms of action of 985-I and A23187.
Type of document
type::text::journal::journal article::research article
ISSN (of the container)
0065-4299
PMID
2455977
Other Identifier(s)
(LSMU ALMA)990000291370107106
Coverage Spatial
Šveicarija / Switzerland (CH)
Language
Anglų / English (en)
Affiliation(s)