Membranous tunneling nanotubes – routes for intercellular communication among laryngeal squamous cell carcinoma cells
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2013-09-06 |
Tunneling nanotubes (TN) and epithelial bridges are recently discovered new forms of intercellular communication between remote cells allowing their electrical synchronization, transfer of second messengers and even membrane vesicles and organelles. TN represent the F-actin-based membranous channels connecting adjacent cells, implicated in intercellular electrical coupling and Ca²+ flux; transfer of organelles or proteins; virus, pathogenic prion transmission; cell migration and bacteria capture. Despite few evidences on existence of TNs in vivo in human pleural mesonthelioma and adenocarcinoma tumor specimens, there is no data in the literature about presence of TNs in malignant tumors of the head and neck region, namely, laryngeal squamous cell carcinoma (LSCC). [...]..