Biochemical blood profile and histophathological changes in liver of rats

Abstract

Introduction. Noise can induce not only hearing loss, but also cause cardiovascular and digestive systems impairements. Xue et al (2014) indicated that noise could lead to pathological changes in the liver because exposure to noise increases the level of oxygen free radicals and lipid peroxidation. The aim of this study was to investigate the influence of long-term building construction noise on some blood biochemical parameters and histopathological changes in the liver of Wistar rats. Materials and methods. Wistar rats (n=20) were kept in two different premises (No. 1 and No. 2) under the same conditions. Animals were housed in a room temperature of 22-24°C with 55±5% humidity, under a 12h:12h light/dark cycle. Rats group I (control) were kept in building the No. 1 which was located more than two hundred meters from refurbished building. Rats of group II were held in premises No. 2 which was located less than one hundred meters away from the construction site and the noise level was more than 60 dB. All rats were given ad libitum access to high-quality standard diet for rodents and water. Animals were housed in standard polycarbonate cages, where minimum enclosure size was 800 cm², floor area per animal - 350 cm² and minimum 18 cm height according to the requirements of Directive 2010/63 EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. [...].