Use this url to cite publication: https://hdl.handle.net/20.500.12512/41486
Фармакологическое изучение некоторых четвертичных производных тримекаина
Type of publication
Straipsnis kitoje duomenų bazėje / Article in other database (S4)
Author(s)
| Author | Affiliation |
|---|---|
Гeндeнштeйн, Э И | |
Цыбуcoв, AП | |
Bukauskas, Feliksas | |
Title
Фармакологическое изучение некоторых четвертичных производных тримекаина
Э. И. Гeндeнштeйн, A. П. Цыбуcoв, Л. Н. Жукaуcкaйтe, A. П. Cтанкявичюc, Ф. Ф. Букaуcкac, B. А. Mизepac
Other Title
Pharmacological study of quaternary trimecaine derivatives
Extent
p. 36-40.
Is part of
Фармакология и токсикология. Москва : Медицина, 1983, т. 46, № 4.
Version
Originalus / Original
Research Area
Gamtos mokslai / Natural Sciences (N)
Field of Science
Biofizika / Biophysics (N011)
Abstract
It has been demonstrated in experiments on cats, rabbits, white rats and mice that the quaternary derivatives of trimecaine (QDT) produce a protective and antiarrhythmic action in atrial (acetylcholine and aconitine) and ventricular (aconitine and calcium chloride) fibrillation. The relationship has been found between the characteristics of the radical at the quaternary nitrogen atom and the antiarrhythmic activity of the QDT. The effect of the QDT on the electrophysiological parameters of the myocardium not on the hemodynamics have been examined. It has been shown that the QDT might be suggested for use as new antiarrhythmic agents.
Media Type (COAR)
TextJournalJournal articleResearch article
ISSN (of the container)
0014-8318
PMID
6617835
Other Identifier(s)
(LSMU ALMA)990000206980107106
Coverage Spatial
Rusija / Russian Federation (RU)
Language
Rusų / Russian (ru)