Effect of Magnesium Aluminum Metasilicate on the Quality of Water-dispersible Tablets with Guarana Dry Extract
| Date | Issue | Start Page | End Page |
|---|---|---|---|
2024-03-22 | 1 | 65 | 65 |
Abstracts of Poster Section
Background: During the production of water-dispersible tablets with dry guarana extract, poor physical, chemical, and mechanical properties such as high hygroscopicity, stickiness, bulkiness and compressibility are observed [1]. To solve these problems, magnesium aluminum metasilicate can be used, which is characterized by good compressibility, it improves the technological properties of powders with plant extracts, the time of disintegration, and the hardness of tablets [2]. Aim: To produce guarana dry extract water-dispersible tablets using the multifunctional material magnesium aluminum metasilicate and to evaluate the quality of the tablets. Methods: Appropriate concentrations of magnesium aluminum metasilicate were chosen. When studying the properties of the tablet mixture, flowability, angle of repose, tapped density, bulk density, compressibility index and Hausner ratio were determined. Quality tests of tablets were performed: uniformity of mass, friability of tablets, resistance to crushing of tablets and disintegration of tablets were determined. Results: After adding different amounts of magnesium aluminum metasilicate to the mixtures, the properties of the powder improved. Based on the obtained results, it was decided to apply direct compression method to produce tablets. The optimal concentration of magnesium aluminum metasilicate to produce water-dispersible tablets with guarana dry extract is 30%. It was found that with this concentration of magnesium aluminum metasilicate, the tablets meet the requirements of the European Pharmacopoeia for mass uniformity, resistance to crushing – 32.6 N, friability – 99%, disintegration time – 01:06 minutes. The mass deviation of the manufactured tablets is within the permissible limits of ±7.5%, the resistance to crushing is between 30-40 newtons, the resistance to dilution is at least 99%, the disintegration time is up to 3 minutes. Conclusion: The insertion of magnesium aluminum metasilicate into powder mixtures with dry guarana extract improved the technological properties of the powder mixtures, because of which high-quality water-dispersible tablets were produced.