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  • research article
    Bhattacharyay, Shubhayu
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    van Leeuwen, Florian D
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    Beqiri, Erta
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    Åkerlund, Cecilia A I
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    Wilson, Lindsay
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    Steyerberg, Ewout W
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    Nelson, David W
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    Maas, Andrew I R
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    Menon, David K
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    Ercole, Ari
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    CENTER-TBI investigators and participants
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    Ragauskas, Arminas
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    Rocka, Saulius
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    Scientific Reports, 2025-01-02, vol. 15, no. 1, p. 1-18

    Practices for controlling intracranial pressure (ICP) in traumatic brain injury (TBI) patients admitted to the intensive care unit (ICU) vary considerably between centres. To help understand the rational basis for such variance in care, this study aims to identify the patient-level predictors of changes in ICP management. We extracted all heterogeneous data (2008 pre-ICU and ICU variables) collected from a prospective cohort (n = 844, 51 ICUs) of ICP-monitored TBI patients in the Collaborative European NeuroTrauma Effectiveness Research in TBI study. We developed the TILTomorrow modelling strategy, which leverages recurrent neural networks to map a token-embedded time series representation of all variables (including missing values) to an ordinal, dynamic prediction of the following day's five-category therapy intensity level (TIL(Basic)) score. With 20 repeats of fivefold cross-validation, we trained TILTomorrow on different variable sets and applied the TimeSHAP (temporal extension of SHapley Additive exPlanations) algorithm to estimate variable contributions towards predictions of next-day changes in TIL(Basic). Based on Somers' Dxy, the full range of variables explained 68% (95% CI 65-72%) of the ordinal variation in next-day changes in TIL(Basic) on day one and up to 51% (95% CI 45-56%) thereafter, when changes in TIL(Basic) became less frequent. Up to 81% (95% CI 78-85%) of this explanation could be derived from non-treatment variables (i.e., markers of pathophysiology and injury severity), but the prior trajectory of ICU management significantly improved prediction of future de-escalations in ICP-targeted treatment. Whilst there was no significant difference in the predictive discriminability (i.e., area under receiver operating characteristic curve) between next-day escalations (0.80 [95% CI 0.77-0.84]) and de-escalations (0.79 [95% CI 0.76-0.82]) in TIL(Basic) after day two, we found specific predictor effects to be more robust with de-escalations. The most important predictors of day-to-day changes in ICP management included preceding treatments, age, space-occupying lesions, ICP, metabolic derangements, and neurological function. Serial protein biomarkers were also important and may serve a useful role in the clinical armamentarium for assessing therapeutic needs. Approximately half of the ordinal variation in day-to-day changes in TIL(Basic) after day two remained unexplained, underscoring the significant contribution of unmeasured factors or clinicians' personal preferences in ICP treatment. At the same time, specific dynamic markers of pathophysiology associated strongly with changes in treatment intensity and, upon mechanistic investigation, may improve the timing and personalised targeting of future care.

  • conference paper
    Contemporary Pharmacy: Issues, Challenges and Expectations 2025 : April 10, 2025 : Abstract book, 2025-04-10, no. 2, p. 18-18

    Background: During the Soviet era, higher education institutions in Lithuania operated under strict ideological control. However, students found ways to express themselves through informal cultural and social activities. The Faculty of Pharmacy at the Kaunas Medical Institute (KMI) was no exception, as students engaged in various extracurricular activities that allowed them to develop a sense of identity and freedom within the restrictive Soviet system. Aim(s): To explore the non-formal activities of pharmacy students at KMI from 1979 to 1989, highlighting their role in shaping a generation that later contributed to the development of an independent Lithuania. Methods: The research is based on archival records, personal testimonies, and interviews with former students who participated in extracurricular activities. It also includes an analysis of student publications, photographs, and event documentation from the late Soviet period. Results: Despite the limitations imposed by the Soviet regime, pharmacy students engaged in ethnographic expeditions, student evenings, and artistic performances, including poetry readings and theatrical presentations. The faculty's ethnographic ensemble played a significant role in preserving Lithuanian cultural traditions. Additionally, student-organized events fostered creativity and intellectual discussions that subtly challenged the Soviet ideological framework. Many students involved in these activities later became key figures in Lithuania’s academic, pharmaceutical, and cultural spheres. Conclusion: The non-formal activities of pharmacy students in the last decade of the Soviet era provided a platform for creative and intellectual self-expression. These activities not only enriched student life but also contributed to the broader movement of cultural and national awakening in Lithuania, which played a crucial role in the country’s path to independence.

  • conference paper;
    Contemporary Pharmacy: Issues, Challenges and Expectations 2025 : April 10, 2025 : Abstract book, 2025-04-10, no. 2, p. 14-14

    Background: 100 years ago, the first Lithuanian pharmacy diploma was awarded. A graduation diploma opens new opportunities, making this event significant and widely celebrated throughout history. Traditionally, graduates have marked this milestone together with professors, students, and family members. Aim(s): To analyze the historical development of pharmacy diploma awarding traditions and their transformation under political, historical and cultural influences. Methods: The study employs a historical approach and a photographic analysis to examine the evolution of pharmacy diploma awarding traditions Results: Political changes have influenced the traditions of diploma awarding ceremonies. There is little information about how pharmacy graduates in interwar Lithuania celebrated this occasion. During the post-war period, economic hardships affected graduation events. However, over time, a tradition of the "last lecture" emerged, characterized by a student-organized artistic program, a symbolic will for future pharmacy students, and an abundant feast during the final lecture. The diploma ceremony took place in the Great Hall, where the rector awarded diplomas, and the dean delivered congratulatory speeches. In the years of regained independence, around the 2000s, the tradition of wearing academic regalia emerged. Students rented regalia, following a practice that likely originated in Western Europe or the United States. In interwar Lithuania, academic regalia were not used, although female graduates may have occasionally worn traditional national attire. Over time, the diploma awarding ceremony moved to Žalgiris arena. Certain traditions faded, such as the presence of alcohol, which had been a prominent element for many years, as well as the "last lecture" tradition and the symbolic student testament. Conclusion: Graduation traditions have evolved under the influence of political changes. In the years of independence, Western-style traditions gained prominence, shaping a modernized approach to pharmacy diploma awarding ceremonies.

  • conference paper; ; ; ;
    Contemporary Pharmacy: Issues, Challenges and Expectations 2025 : April 10, 2025 : Abstract book, 2025-04-10, no. 2, p. 20-20

    Background: At all times, pharmacy students not only studied theoretical materials but also conducted various research studies. At Vytautas Magnus University, pharmacy students (pharmacy candidates) who studied between 1930 and 1940 had to pass exams and write a thesis to obtain the title of chemist-pharmacist [1]. Today, pharmacy students apply the latest analytical methodologies when preparing their master's thesis. However, it is important to examine which analytical methods were mentioned in the pre-war pharmacy candidates' theses. Aim: To find out the topics and analytical methods used in pharmacy candidates' theses from 1930 to 1940. Methods: A review of pharmacy candidates' theses stored at the Museum of the History of Lithuanian Medicine and Pharmacy of LSMU. Results: Pharmacy candidates conducted research on pharmaceutical preparations and household products. It was found that complex pharmaceutical preparations (ointments, powders, solutions), food products (sour cream, bread, apples, mineral water, alcoholic beverages), as well as cleaning agents, smoking tobacco, and church candles were analyzed. Students carried out synthesis work (extraction of trimethylamine from herring brine) and the isolation of active substances from biological samples (the thyroid gland, blood, and liver of animals). It was found that qualitative and quantitative methods of chemical analysis were used, but no instrumental methods were described. The theses documented the use of microscopic, volumetric, and gravimetric analysis methods; as well as a detailed process of sample preparation and the calculation of results. Test samples were analyzed for ash content, moisture, organic compounds (sugar, proteins, nicotine, pyridine, fusel oils, ethyl and methyl alcohols), as well as inorganic compounds and elements (carbonates, ammonium, iron, calcium, magnesium, sodium, potassium, etc.). Conclusion: Between 1930 and 1940, pharmacy candidates explored a variety of topics, and their theses were based on experimental research, demonstrating the broad scope expected of a chemist-pharmacist.

  • conference paper
    Contemporary Pharmacy: Issues, Challenges and Expectations 2025 : April 10, 2025 : Abstract book, 2025-04-10, no. 2, p. 19-19

    This paper presents research on the egodocumentary heritage of Vytautas Civinskis (1887–1910). It aims to show the opportunities available to students at German-speaking European universities at the turn of the 19th and 20th centuries and how a young man from Lithuania made use of them. The methods include case analysis, analysis of primary and secondary sources, historical reconstruction. In the second half of the 19th century, the universities in German-speaking countries stood out strongly in developing science and offering study opportunities. Youth from foreign countries took advantage of these opportunities. Vytautas Civinskis, who started studying agriculture at Leipzig University in 1904, was among them. But the revolutionary events of 1905 in the Russian Empire changed his life plans. Instead, Civinskis enrolled in the Royal Veterinary School in Berlin in 1906, and later continued his veterinary studies at the Tartu Veterinary Institute until 1910. We learn from his diary, which was written during his study years, and his personal documents that Civinskis made his individual study plan at Leipzig. Twenty-four subjects are listed in his study card (Kolegienbuch), along with prices and the lecturers’ names and signatures, many famous names among them. The set of subjects was broad: many related to history, politics, as well as philosophy and psychology. The study environment was culturally, socially, and politically diverse as well as multilingual. Conclusion. The Civinskis’ case analysis shows that German-speaking universities were accessible to some of the youth from Lithuania in terms of their ability to pay, level of language proficiency and other skills. However, Lithuanian and Polish youth from the Russian Empire were enrolled in German-speaking universities as Russians. By further investigating such cases, it would be possible to reveal in more detail the impact of German-speaking universities on the Lithuanian educated elite during the late 19th and early 20th centuries.

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  • journal article
    Lietuvos bendrosios praktikos gydytojas. Kaunas : Vitae Litera, 2008, t. 12, Nr. 10., p. 679-681.

    Lėtinis atrofinis gastritas – tai ilgalaikio lėtinio skrandžio uždegimo sąlygota skrandžio gleivinės atrofija. Atrofinio gastrito fone vystosi metaplazija žarninio tipo epiteliu, vėliau epitelio displazija ir skrandžio vėžys. Atrofija ir žarninė metaplazija apibūdinamos kaip ikivėžinės būklės. Skrandžio gleivinės atrofija ir žarninė metaplazija yra dažnesnės šalyse, kuriose yra didelis sergamumas skrandžio vėžiu. Atrofinis gastritas laikomas ikivėžine liga, tačiau nėra visiškai aišku, ar galimas atrofijos proceso sustabdymas, ar tai leidžia apsaugoti nuo skrandžio vėžio.

      4640
  • conference paper
    7th Japan-Lithuania Joint Life Sciences Symposium: New approach to Life Sciences“ : 18 December, 2020 / Lithuanian University of Health Sciences. Kaunas : Lithuanian University of Health Sciences, 2020., 2020-12-18, p. 1-1

    Voice disorders (hoarseness) are a common condition manifesting in almost 10% of the population. The causes of hoarseness can be related to common respiratory diseases and/or to vocal fatigue caused by vocal overload, however it can also be related to functional, behavioral, neurologic factors and both benign and malignant laryngeal tumors. Hoarseness can also be an early symptom of laryngeal cancer. The VoiceScreen app requires the user to perform two simple tasks: 1). Sustain a vowel [a:] sound for 4 seconds, 2) Read the provided sentence. The users’ voice is recorded and then analyzed extracting six acoustic voice function parameters which are then weighted and merged together to provide the user with the Acoustic Voice Quality Index (AVQI) of his/her voice. The value of AVQI as a clinical marker of overall voice quality has already been proven across multiple studies revealing adequate diagnostic accuracy. The AVQI values do not depend on gender and age. The VoiceScreen app calculates and displays the value of AVQI and also provides the user with recommendations based on the test results. The provided recommendations should be taken as guidance on what to do next to help the user’s voice. [...].

      3987
  • Publication
    Vidutinio trombocitų tūrio sąsajos su lėtiniu prieširdžių virpėjimu ir periferinių arterijų liga
    [Mean platelet volume: its relation to permanent atrial fibrillation and peripheral artery disease]
    research article; ;
    Medicinos mokslai. Medical sciences. Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras, 2019, vol. 7, no. 12, Oct 31., 2019-11-06, p. 1-6.

    Vidutinis trombocitų tūris (MPV-mean platelet volume) yra bendrojo kraujo tyrimo metu nustatomas rodiklis, kuris apibūdina vidutinį trombocitų dydį ir gali būti susijęs su uždegimu bei tromboze. Didesnis MPV yra susijęs su didesne išeminio insulto, ūminio miokardo infarkto, giliųjų venų trombozės bei plaučių arterijų trombembolijos rizika. Tyrimo tikslas - nustatyti MPV sąsajas su lėtiniu prieširdžių virpėjimu (PV) ir periferinių arterijų liga (PAL). Į tyrimą įtraukta 180 pacientų, kurie suskirstyti į grupes: sergančių lėtiniu PV pacientų ir pacientų, kuriems registruotas sinusinis ritmas. Visiems tiriamiesiems apskaičiuotas kulkšnies-žasto indeksas (KŽI), sistolinio arterinio kraujo spaudimo kojose matavimui naudotas 5-MHz dopleris. PAL diagnozuota, kai KŽI gautas <0,9. MPV reikšmės buvo didesnės pacientams sergantiems lėtiniu PV (kontrolinėje grupėje 8,635±1,476 fl, tiriamojoje grupėje 9,131±1,202 fl) (p=0,015). Pacientai, kuriems nustatytas KŽI<0,9 ir MPV>8,55 fl, dažniau sirgo lėtiniu PV nei pacientai, kurių KŽI>0,9, o MPV<8,55 fl (p=0,001). Didesnis MPV buvo susijęs su didesne PAL tikimybe (ŠS 1,608, 95% PI 1,243 – 2,081) (p=0,001) nepriklausomai nuo lyties ir amžiaus (koreguotas ŠS 1,612, 95% PI 1,248 – 2,098) (p=0,001). PAL sergantiems pacientams buvo nustatytas didesnis MPV, kritinė MPV reikšmė - 8,55 fl. MPV reikšmei esant 8,55 fl, rodiklio jautrumas PAL nustatymui buvo 76%, o specifiškumas – 61%.

      3294
  • journal article;
    Lietuvos bendrosios praktikos gydytojas. Kaunas : Vitae Litera, 2017, t. 21, Nr. 2., 2017-03-13, p. 122-125.

    Mezenterinis panikulitas (MP) – reta patologija, apibūdinama kaip lėtinis, nespecifinis žarnyno pasaito riebalinio audinio uždegimas. Ligos paplitimas – 0,16-2,5 proc. Vyrams ši patologija dažnesnė nei moterims, santykis – 2-3:1. Pagrindinis patogeninis mechanizmas yra nespecifinis uždegiminis atsakas į skirtingus etiologiniuis faktorius, tačiau tikslios priežastys iki šiol nepakankamai ištirtos. Histologiškai išskiriamos trys ligos progresavimo stadijos. Dažniausiai ši liga yra besimptomė ir nustatoma atsitiktinai, kitais atvejais simptomai būna nespecifiniai ir kintami. Kompiuterinė tomografija yra pagrindinis tyrimas MP diagnozei nustatyti. Tiksliai diagnozei patvirtinti reikalinga ekscizinė biopsija ir histologinis tyrimas. Nėra visuotinai priimto sutarimo, kokį gydymą skirti, rekomenduojama gydyti imunomoduliatoriais, priešuždegiminiais, antifibrotiniais vaistais. Chirurginis gydymas gali būti taikomas, jei konservatyvusis gydymas neveiksmingas arba yra gyvybei pavojingų komplikacijų.

      3104
  • book; ;
    Tutkuvienė, Janina
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    Schumacher, Gert Horst
    Kaunas : Lietuvos sveikatos mokslų universiteto Leidybos namai, 2016., 2016-10-02

    Vadovėlyje "Žmogaus anatomija" aprašoma žmogaus išorinė ir vidinė sandara organų sistemų, vykdančių organizmo kraujo ir limfos apykaitą, imuninę apsaugą, nervinę ir endokrininę reguliaciją, pateikiama organų raidos schema, pabrėžiama anatominių savitumų medicininė reikšmė. Vadovėlis skiriamas biomedicinos krypties medicinos ir odontologijos studijoms, juo galės naudotis ir rezidentai, doktorantai ir kiti specialistai. Vilniaus ir Kauno medicinos anatomai, 2003 m. rekomendavus LR švietimo ir mokslo ministerijos Aukštųjų mokyklų bendrųjų vadovėlių leidybos komisijai, parengė dviejų dalių vadovėlį „Žmogaus anatomija". Antroji jo dalis, parengta Kauno anatomų, padedant Vilniaus anatomei prof. Janinai Tutkuvienei, buvo išleista 2007 m., o pataisyta 2-oji laida - 2008 m. Šioje dalyje pateiktos anatomijos žinios apie organų sistemas, vykdančias organizmo kraujo ir limfos apykaitą, imuninę apsaugą, nervinę ir endokrininę reguliaciją, apie jutimo organus ir odą. Į šio vadovėlio autorių sąrašą taip pat buvo įtrauktas vokiečių anatomas Gertas-Horstas Šumacheris, leidęs vartoti kai kurias jo anatomijos vadovėlio iliustracijas.Sudėvėti vadovėlio egzemplioriai skaityklose ir jų dingimas knygynų lentynose rodo, kad jis turėjo paklausą, buvo naudingas siekiantiems anatomijos žinių žmonėms. Autoriams malonu tai žinoti ir esame dėkingi LSMULeidybos namams, sumaniusiems išleisti dar vieną jo laidą. Tad atsirado gera proga šioje laidoje, iš esmės nekeičiant vadovėlio dalykinio turinio, atlikti kai kuriuos pataisymus, papildymus ir jo sandaros pakeitimus. Pirmiausia buvo ištaisytos pačių autorių ir skaitytojų pastebėtos techninės ir dalykinės klaidos, koreguoti kai kurie lietuviški anatomijos terminai, atnaujinta bei išplėsta lietuviškų ir lotyniškų terminų rodyklė. Kai kurie skyriai papildyti aprašomų organų ontogenezės,

      3062  226
Most downloaded
Most WOS cited
  • journal article
    Patterson, Chris C
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    Dahlquist, Gisela
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    Harjutsalo, V
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    Joner, Geir
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    Feltbower, Richard G
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    Svensson, Jannet
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    Schober, Edith
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    Gyürüs, Eva
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    Castell, Conxa
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    Rosenbauer, Joachim
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    Iotova, Violeta
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    Thorsson, Arni V
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    Soltesz, Gyula
    Diabetologia. Berlin : Springer, 2007, vol. 50, no. 12., 2007-08-07, p. 2439-2442.

    Aims/hypothesis The aims of this study were to provide a contemporary picture of mortality and causes of death in Europe following a diagnosis of type 1 diabetes made before the 15th birthday, and to examine excess mortality by country for possible links to incidence level or national prosperity. Methods Thirteen population-based EURODIAB registers in 12 countries followed-up 28,887 children diagnosed since 1989, either by record linkage to population registers or through contact with doctors providing care. Results There were 141 deaths in the cohort during 219,061 person-years of follow-up compared with 69.1 deaths expected from national mortality rates, a standardised mortality ratio (SMR) of 2.0 (95% CI 1.7–2.4). The SMR varied from 0 to 4.7 between countries, but showed little relationship with the country’s incidence rate or gross domestic product (US$ per capita). The SMR did not change significantly with attained age, calendar period or time since diagnosis. The female SMR (2.7; 95% CI 2.0–3.5) was greater than the male SMR (1.8; 95% CI 1.4–2.2), although absolute numbers of excess deaths were similar in the two sexes. One-third of deaths were classified as directly attributable to diabetes (many with mention of ketoacidosis) and half were unrelated to diabetes. There was a non-significant excess of accidental/violent deaths (48 observed vs 40.7 expected; SMR 1.2; 95% CI 0.9–1.6) but little excess in suicides (11 observed, 10.2 expected; SMR 1.1; 95% CI 0.5–1.9). Conclusions/interpretation Before the onset of late complications, significant excess mortality existed following the diagnosis of type 1 diabetes in childhood, even in recent years. Variation between countries in this excess could not be explained. Electronic supplementary material The online version of this article (doi:10.1007/s00125-007-0824-8) contains supplementary material, which is available to authorised users.

      5
  • conference paper; ;
    Šmidt, A.
    Уcпexи гeпaтoлoгии. Pига, 1971., p. 292-310.
      5
  • conference paper
    Saunoriūtė, Sandra
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    63rd International conference for students of physics and natural sciences Open Readings 2020 : 17-20 March 2020, Vilnius, Lithuania : abstract book / Faculty of Physics. Vilnius University. Vilnius : Vilnius University, 2020. ISBN 9786090703779., 2020-03-17, p. 507-507

    Chemical analysis of spice, aromatic plants at different vegetation stages can serve for the optimal collection of plant raw material revealing the period when the plant possesses the highest biological activity and accumulates the highest content of biologically active compounds, which could be used in pharmacy, medicine, food or cosmetic industry [1]. The aim of this study was to investigate the qualitative and quantitative composition of essential oils obtained from A. absinthium during different vegetation stages. The object of investigation was Artemisia absinthium L. a perennial medicinal, aromatic plant of Asteraceae (Bercht. & J. Presl) family. A. absinthium is widely used in the Lithuanian folk medicine mainly for stomachic and anthelmintic activity, also for healing gall-bladder and kidneys diseases, against insomnia, diarrhea [3, 5, 6, 7]. Raw material of A. absinthium was collected during different vegetation stages of vegetation cycle in Spice − Melliferous plants collection ex situ of Botanical Garden at Vytautas Magnus University in 2018. Five stages have been separated: growth and leaf production, flower bud development, beginning of the flowering, massive flowering, end of the flowering [4]. The essential oils have been extracted by hydrodistillation method and analysed by the chromatographic techniques in the gas phase and chromatography in gas phase coupled with mass spectrometry (GC/MS) so as to determine their chemical composition. The percentage composition of the essential oils was computed from GC peak areas without correction factors. Qualitative analysis was based on a comparison of retention times, indexes and mass spectra with the corresponding data in the literature [2] and computer mass spectra libraries. There were studied 5 samples of A. absinthium considering different vegetation stages. A total of 81 different compounds were found in the essential oils. The data showed the...[...].

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  • conference paper;
    Matulis, Daumantas
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    Vita Scientia : International conference „Vita Scientia“ : conference book : 3rd January, 2018, Vilnius / Vilnius University. Vilnius : Vita est Scientia, 2018, 2018., 2018-01-03, p. 53-54

    Heat shock protein 90 (Hsp90) is a molecular chaperone with over 200 identified client proteins. This chaperone protein is crucial for protein folding and stabillization and interfere in many pathways of cancer cells, therefore it is a potential target for anticancer therapy. Hsp90 inhibitors bind to the N-terminal ATP domain of Hsp90, and several of them have entered clinical trials. Recent studies show that Hsp90 inhibitors in combination with clinically used chemotherapeutic agents may act synergistically, therefore such effect can reduce the dose and toxicity of used drugs, and minimize or delay the induction of drug resistance [1]. The aim of our study was to evaluate activity of different combinations of two Hsp90 inhibitors (ICPD47 and ICPD62) and three anticancer agents (gemcitabine, 5fluorouracil and doxorubicin) against pancreatic cancer cells. The effect of Hsp90 inhibitors, other agents and different combinations on cell viability was evaluated by MTT assay in two pancreatic cancer cell lines: MIA PaCa-2 and Panc-1. The type of combination effect was determined by calculating combination index (CI), using CompuSyn software based on Chou-Talalay method [2]. Synergism was considered when CI < 1, antagonism when CI > 1, and CI value of 1 defined an additive effect of the drug combination. Results. Among tested Hsp90 inhibitors ICPD62 had the greatest effect on cell viability (EC50 values after 72 h on MIA PaCa-2 and Panc-1 were 0.446 ± 0.06 µM and 0.41 ± 0.08 µM, respectively) and among other anticancer agents doxorubicin showed the greatest effect on cell viability (EC50 values after 72 h on MIA PaCa-2 and Panc-1 were 0.076 ± 0.03 µM and 0.074 ± 0.02 µM, respectively). The combination of ICPD47 and gemcitabine with concentration ratio 5:1, showed the greatest synergistic activity in MIA PaCa-2 cell line (CI = 0.192, when fa = 0.5), and the combination of ICPD62 and gemcitabine with concentration rat[...].

      10
  • research article
    Теория и практика автоматизации в кардиологии : [тематический сборник научных трудов ИБС] / [Редкол.: З.И. Янушкевичус (отв. ред.) и др.] ; Министерство высшего и среднего специального образования Литовской ССР. Научно-исследовательский институт физиологии и патологии сердечно-сосудистой системы при Каунасском медицинском институте. Вильнюс : Редакционно-издательский совет М-во высш. и сред. спец. образования ЛитССР, 1980., p. 3-11.

    Распространение сердечно-сосудистых заболеваний и расширение объема борьбы с ними обусловило значительное увеличение масштабов обследования населения. Обработка этих данных, обязательно включающих электрокардиологические показатели, уже невозможна без применения математических методов и вычислительной техники. Первые работы по применению ЭВМ для анализа электрокардиограмм (ЭКГ) появились в конце пятидесятых годов, а в начале шестидесятых – первые экспериментальные системы анализа ЭКГ, промышленный выпуск которых начался в конце шестидесятых годов в США. По данным Кейсерс, только в США в 1970 году около 50 фирм м компаний занимались разработкой и распространением систем компьютерного анализа ЭКГ. По данным Rautaharju, в настоящее время в капиталистических странах действуют по крайней мере 20 больших центров комьютерного анализа ЭКГ, которые в 1976 году проанализировали около 5 миллионов ЭКГ, в том числе фирмы IBM и Telemed по 1 миллиону 400 тысяч ЭКГ, фирма Hewlett-Packard – 600.000 ЭКГ. [...].

      5
Most SCOPUS cited
  • journal article
    Patterson, Chris C
    ;
    Dahlquist, Gisela
    ;
    Harjutsalo, V
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    Joner, Geir
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    Feltbower, Richard G
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    Svensson, Jannet
    ;
    Schober, Edith
    ;
    Gyürüs, Eva
    ;
    Castell, Conxa
    ;
    ;
    Rosenbauer, Joachim
    ;
    Iotova, Violeta
    ;
    Thorsson, Arni V
    ;
    Soltesz, Gyula
    Diabetologia. Berlin : Springer, 2007, vol. 50, no. 12., 2007-08-07, p. 2439-2442.

    Aims/hypothesis The aims of this study were to provide a contemporary picture of mortality and causes of death in Europe following a diagnosis of type 1 diabetes made before the 15th birthday, and to examine excess mortality by country for possible links to incidence level or national prosperity. Methods Thirteen population-based EURODIAB registers in 12 countries followed-up 28,887 children diagnosed since 1989, either by record linkage to population registers or through contact with doctors providing care. Results There were 141 deaths in the cohort during 219,061 person-years of follow-up compared with 69.1 deaths expected from national mortality rates, a standardised mortality ratio (SMR) of 2.0 (95% CI 1.7–2.4). The SMR varied from 0 to 4.7 between countries, but showed little relationship with the country’s incidence rate or gross domestic product (US$ per capita). The SMR did not change significantly with attained age, calendar period or time since diagnosis. The female SMR (2.7; 95% CI 2.0–3.5) was greater than the male SMR (1.8; 95% CI 1.4–2.2), although absolute numbers of excess deaths were similar in the two sexes. One-third of deaths were classified as directly attributable to diabetes (many with mention of ketoacidosis) and half were unrelated to diabetes. There was a non-significant excess of accidental/violent deaths (48 observed vs 40.7 expected; SMR 1.2; 95% CI 0.9–1.6) but little excess in suicides (11 observed, 10.2 expected; SMR 1.1; 95% CI 0.5–1.9). Conclusions/interpretation Before the onset of late complications, significant excess mortality existed following the diagnosis of type 1 diabetes in childhood, even in recent years. Variation between countries in this excess could not be explained. Electronic supplementary material The online version of this article (doi:10.1007/s00125-007-0824-8) contains supplementary material, which is available to authorised users.

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  • conference paper; ;
    Šmidt, A.
    Уcпexи гeпaтoлoгии. Pига, 1971., p. 292-310.
      5
  • conference paper
    Saunoriūtė, Sandra
    ;
    ; ;
    63rd International conference for students of physics and natural sciences Open Readings 2020 : 17-20 March 2020, Vilnius, Lithuania : abstract book / Faculty of Physics. Vilnius University. Vilnius : Vilnius University, 2020. ISBN 9786090703779., 2020-03-17, p. 507-507

    Chemical analysis of spice, aromatic plants at different vegetation stages can serve for the optimal collection of plant raw material revealing the period when the plant possesses the highest biological activity and accumulates the highest content of biologically active compounds, which could be used in pharmacy, medicine, food or cosmetic industry [1]. The aim of this study was to investigate the qualitative and quantitative composition of essential oils obtained from A. absinthium during different vegetation stages. The object of investigation was Artemisia absinthium L. a perennial medicinal, aromatic plant of Asteraceae (Bercht. & J. Presl) family. A. absinthium is widely used in the Lithuanian folk medicine mainly for stomachic and anthelmintic activity, also for healing gall-bladder and kidneys diseases, against insomnia, diarrhea [3, 5, 6, 7]. Raw material of A. absinthium was collected during different vegetation stages of vegetation cycle in Spice − Melliferous plants collection ex situ of Botanical Garden at Vytautas Magnus University in 2018. Five stages have been separated: growth and leaf production, flower bud development, beginning of the flowering, massive flowering, end of the flowering [4]. The essential oils have been extracted by hydrodistillation method and analysed by the chromatographic techniques in the gas phase and chromatography in gas phase coupled with mass spectrometry (GC/MS) so as to determine their chemical composition. The percentage composition of the essential oils was computed from GC peak areas without correction factors. Qualitative analysis was based on a comparison of retention times, indexes and mass spectra with the corresponding data in the literature [2] and computer mass spectra libraries. There were studied 5 samples of A. absinthium considering different vegetation stages. A total of 81 different compounds were found in the essential oils. The data showed the...[...].

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  • conference paper;
    Matulis, Daumantas
    ;
    Vita Scientia : International conference „Vita Scientia“ : conference book : 3rd January, 2018, Vilnius / Vilnius University. Vilnius : Vita est Scientia, 2018, 2018., 2018-01-03, p. 53-54

    Heat shock protein 90 (Hsp90) is a molecular chaperone with over 200 identified client proteins. This chaperone protein is crucial for protein folding and stabillization and interfere in many pathways of cancer cells, therefore it is a potential target for anticancer therapy. Hsp90 inhibitors bind to the N-terminal ATP domain of Hsp90, and several of them have entered clinical trials. Recent studies show that Hsp90 inhibitors in combination with clinically used chemotherapeutic agents may act synergistically, therefore such effect can reduce the dose and toxicity of used drugs, and minimize or delay the induction of drug resistance [1]. The aim of our study was to evaluate activity of different combinations of two Hsp90 inhibitors (ICPD47 and ICPD62) and three anticancer agents (gemcitabine, 5fluorouracil and doxorubicin) against pancreatic cancer cells. The effect of Hsp90 inhibitors, other agents and different combinations on cell viability was evaluated by MTT assay in two pancreatic cancer cell lines: MIA PaCa-2 and Panc-1. The type of combination effect was determined by calculating combination index (CI), using CompuSyn software based on Chou-Talalay method [2]. Synergism was considered when CI < 1, antagonism when CI > 1, and CI value of 1 defined an additive effect of the drug combination. Results. Among tested Hsp90 inhibitors ICPD62 had the greatest effect on cell viability (EC50 values after 72 h on MIA PaCa-2 and Panc-1 were 0.446 ± 0.06 µM and 0.41 ± 0.08 µM, respectively) and among other anticancer agents doxorubicin showed the greatest effect on cell viability (EC50 values after 72 h on MIA PaCa-2 and Panc-1 were 0.076 ± 0.03 µM and 0.074 ± 0.02 µM, respectively). The combination of ICPD47 and gemcitabine with concentration ratio 5:1, showed the greatest synergistic activity in MIA PaCa-2 cell line (CI = 0.192, when fa = 0.5), and the combination of ICPD62 and gemcitabine with concentration rat[...].

      10
  • research article
    Теория и практика автоматизации в кардиологии : [тематический сборник научных трудов ИБС] / [Редкол.: З.И. Янушкевичус (отв. ред.) и др.] ; Министерство высшего и среднего специального образования Литовской ССР. Научно-исследовательский институт физиологии и патологии сердечно-сосудистой системы при Каунасском медицинском институте. Вильнюс : Редакционно-издательский совет М-во высш. и сред. спец. образования ЛитССР, 1980., p. 3-11.

    Распространение сердечно-сосудистых заболеваний и расширение объема борьбы с ними обусловило значительное увеличение масштабов обследования населения. Обработка этих данных, обязательно включающих электрокардиологические показатели, уже невозможна без применения математических методов и вычислительной техники. Первые работы по применению ЭВМ для анализа электрокардиограмм (ЭКГ) появились в конце пятидесятых годов, а в начале шестидесятых – первые экспериментальные системы анализа ЭКГ, промышленный выпуск которых начался в конце шестидесятых годов в США. По данным Кейсерс, только в США в 1970 году около 50 фирм м компаний занимались разработкой и распространением систем компьютерного анализа ЭКГ. По данным Rautaharju, в настоящее время в капиталистических странах действуют по крайней мере 20 больших центров комьютерного анализа ЭКГ, которые в 1976 году проанализировали около 5 миллионов ЭКГ, в том числе фирмы IBM и Telemed по 1 миллиону 400 тысяч ЭКГ, фирма Hewlett-Packard – 600.000 ЭКГ. [...].

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