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  • research article
    Kasprowicz, Magdalena
    ;
    Mataczyński, Cyprian
    ;
    Uryga, Agnieszka
    ;
    Pelah, Adam I
    ;
    Schmidt, Eric
    ;
    Czosnyka, Marek
    ;
    Kazimierska, Agnieszka
    ;
    CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
    ;
    Ragauskas, Arminas
    ;
    Rocka, Saulius
    ;
    ;
    Critical Care (London, England), 2025-02-17, vol. 29, no. 1, p. 1-12

    Morphological analysis of intracranial pressure (ICP) pulse waveforms provides indirect information on cerebrospinal compliance, which might be reduced by space-occupying lesions but also by intracranial hypertension and aging. This study investigates the impact of age and mean ICP on the shape and amplitude of ICP pulse waveform in traumatic brain injury (TBI). Additionally, it explores the association between morphological parameters and mortality after TBI.

  • research article
    Ritzer, Lukas
    ;
    Harris, Alon
    ;
    Arciero, Julia
    ;
    Siesky, Brent
    ;
    Fry, Brendan
    ;
    ;
    Oddone, Francesco
    ;
    Carnevale, Carmela
    ;
    Eckert, George
    ;
    Verticchio Vercellin, Alice
    Journal of Glaucoma, 2025-04-01, vol. 34, no. 4, p. 267-274

    The relationship between structural and hemodynamic parameters in patients with primary open angle glaucoma is strongest in the temporal region of the optic nerve.

  • preprint
    Hansen, Matilde Bøgelund
    ;
    Lykkegaard, Jesper
    ;
    Hansen, Malene Plejdrup
    ;
    Llor, Carl
    ;
    Sangenis, Ana Garcia
    ;
    Touboul-Lundgren, Pia
    ;
    Pascale, Bruno
    ;
    Radzevičienė, Rūta
    ;
    ;
    Anastasaki, Marilena
    ;
    Lionis, Christos
    ;
    Kowalczyk, Anna
    ;
    Godycki-Ćwirko, Maciek
    ;
    Lopez-Valcárcel, Beatriz Gonzalez
    ;
    Floriano, Fabiana Raynal
    ;
    Chalkidou, Athina
    ;
    Bjerrum, Lars
    ;
    Jensen, Jette Nygaard
    European Geriatric Medicine, 2025-03-27, vol. 00, no. 00, p. 1-12

    Antibiotic use is the main driver of bacterial antimicrobial resistance. Urinary tract infections (UTIs), for which antibiotics are often prescribed, are among the most common infections among residents in nursing homes. This study aimed to estimate and compare the appropriateness of antibiotic use for suspected UTIs among nursing home residents across five European countries. Both the decision to treat and the choice of antibiotics used were explored.

  • research article
    Baršytė, Eigilė
    ;
    ;
    Journal of Oral and Maxillofacial Research (JOMR), 2025-04-01, vol. 16, no. 1, p. 1-10

    Objectives: This cross-sectional observational study aims to identify the prevalence of musculoskeletal disorders among Lithuanian dentists and dental hygienists and determine the most affected body areas. Material and Methods: An anonymous survey was carried out from October 20, 2024, to December 5, 2024. The questionnaire was distributed online to Lithuanian specialists - dentists and oral hygienists. A total of 382 professionals were included in this survey. Chi-square test, its degrees of freedom was used for the analysis of variables. Results: The study involved 382 participants who reported experiencing pain in the neck (65.7%), shoulders (59.7%), and lower back (58.1%) in the past 12 months, while only 4.5% did not experience any discomfort. Based on the study data, 19.4% of respondents were unable to perform their regular work due to problems related to pain in certain areas during the last 12 months. In addition, 49.5% of specialists had never consulted a physiotherapist or doctor about their condition during the past year. As many as 20.7% of respondents stated that they were completely physically inactive, and 18.1% engaged in low-intensity physical activity. Conclusions: Overall, dentists and dental hygienists in Lithuania face a significant prevalence of work-related musculoskeletal disorders in their profession. Considering the magnitude of this issue, it is essential to implement university-level preventive education programs that provide dental professionals with comprehensive ergonomic knowledge.

  • research article
    Pilarczyk, Bogumiła
    ;
    Pilarczyk, Renata
    ;
    Juszczak-Czasnojć, Marta
    ;
    Bąkowska, Małgorzata
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    Tomza-Marciniak, Agnieszka
    ;
    Seremak, Beata
    ;
    ;
    Animals, 2025-03-14, vol. 15, no. 6, p. 1-18

    The aim of the study was to determine the extent and intensity of gastrointestinal parasite infections in alpacas (Vicugna pacos) in Poland, considering factors such as region, gender, age, and season. The research was conducted on 29 herds located throughout Poland. Faecal samples from 512 alpacas were collected in autumn 2023 and spring 2024. Examination was performed using the direct flotation and McMaster methods. The average prevalence of gastrointestinal parasitic infections was 74.4%; 68.8% of alpacas were infected with nematodes and 34.8% with protists of the genus Eimeria. The most commonly detected parasites were Nematodirus spp. (38.5%) and Eimeria punoensis (18.2%). The analysis revealed significant differences in the intensity of gastrointestinal parasitic infections depending on region, age, gender, and season, suggesting the need to tailor deworming programs to the specific requirements of different groups of alpacas. Furthermore, regional differences in the prevalence of Strongyloides sp. and Strongylida infections were observed, indicating a significant impact of local environmental conditions and husbandry practices on the risk of infection. Seasonal variations in the intensity of Eimeria infections, particularly in autumn, were also noted. Parasitic infections in alpacas in Poland are common and generally asymptomatic. These results highlight the need for the implementation of a comprehensive preventive program for controlling parasitic infection, including regular diagnostics, pasture management optimization, maintenance of hygiene, and selective use of antiparasitic drugs in alpacas.

Most viewed
  • journal article
    Lietuvos bendrosios praktikos gydytojas. Kaunas : Vitae Litera, 2008, t. 12, Nr. 10., p. 679-681.

    Lėtinis atrofinis gastritas – tai ilgalaikio lėtinio skrandžio uždegimo sąlygota skrandžio gleivinės atrofija. Atrofinio gastrito fone vystosi metaplazija žarninio tipo epiteliu, vėliau epitelio displazija ir skrandžio vėžys. Atrofija ir žarninė metaplazija apibūdinamos kaip ikivėžinės būklės. Skrandžio gleivinės atrofija ir žarninė metaplazija yra dažnesnės šalyse, kuriose yra didelis sergamumas skrandžio vėžiu. Atrofinis gastritas laikomas ikivėžine liga, tačiau nėra visiškai aišku, ar galimas atrofijos proceso sustabdymas, ar tai leidžia apsaugoti nuo skrandžio vėžio.

      4640
  • conference paper
    7th Japan-Lithuania Joint Life Sciences Symposium: New approach to Life Sciences“ : 18 December, 2020 / Lithuanian University of Health Sciences. Kaunas : Lithuanian University of Health Sciences, 2020., 2020-12-18, p. 1-1

    Voice disorders (hoarseness) are a common condition manifesting in almost 10% of the population. The causes of hoarseness can be related to common respiratory diseases and/or to vocal fatigue caused by vocal overload, however it can also be related to functional, behavioral, neurologic factors and both benign and malignant laryngeal tumors. Hoarseness can also be an early symptom of laryngeal cancer. The VoiceScreen app requires the user to perform two simple tasks: 1). Sustain a vowel [a:] sound for 4 seconds, 2) Read the provided sentence. The users’ voice is recorded and then analyzed extracting six acoustic voice function parameters which are then weighted and merged together to provide the user with the Acoustic Voice Quality Index (AVQI) of his/her voice. The value of AVQI as a clinical marker of overall voice quality has already been proven across multiple studies revealing adequate diagnostic accuracy. The AVQI values do not depend on gender and age. The VoiceScreen app calculates and displays the value of AVQI and also provides the user with recommendations based on the test results. The provided recommendations should be taken as guidance on what to do next to help the user’s voice. [...].

      3987
  • Publication
    Vidutinio trombocitų tūrio sąsajos su lėtiniu prieširdžių virpėjimu ir periferinių arterijų liga
    [Mean platelet volume: its relation to permanent atrial fibrillation and peripheral artery disease]
    research article; ;
    Medicinos mokslai. Medical sciences. Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras, 2019, vol. 7, no. 12, Oct 31., 2019-11-06, p. 1-6.

    Vidutinis trombocitų tūris (MPV-mean platelet volume) yra bendrojo kraujo tyrimo metu nustatomas rodiklis, kuris apibūdina vidutinį trombocitų dydį ir gali būti susijęs su uždegimu bei tromboze. Didesnis MPV yra susijęs su didesne išeminio insulto, ūminio miokardo infarkto, giliųjų venų trombozės bei plaučių arterijų trombembolijos rizika. Tyrimo tikslas - nustatyti MPV sąsajas su lėtiniu prieširdžių virpėjimu (PV) ir periferinių arterijų liga (PAL). Į tyrimą įtraukta 180 pacientų, kurie suskirstyti į grupes: sergančių lėtiniu PV pacientų ir pacientų, kuriems registruotas sinusinis ritmas. Visiems tiriamiesiems apskaičiuotas kulkšnies-žasto indeksas (KŽI), sistolinio arterinio kraujo spaudimo kojose matavimui naudotas 5-MHz dopleris. PAL diagnozuota, kai KŽI gautas <0,9. MPV reikšmės buvo didesnės pacientams sergantiems lėtiniu PV (kontrolinėje grupėje 8,635±1,476 fl, tiriamojoje grupėje 9,131±1,202 fl) (p=0,015). Pacientai, kuriems nustatytas KŽI<0,9 ir MPV>8,55 fl, dažniau sirgo lėtiniu PV nei pacientai, kurių KŽI>0,9, o MPV<8,55 fl (p=0,001). Didesnis MPV buvo susijęs su didesne PAL tikimybe (ŠS 1,608, 95% PI 1,243 – 2,081) (p=0,001) nepriklausomai nuo lyties ir amžiaus (koreguotas ŠS 1,612, 95% PI 1,248 – 2,098) (p=0,001). PAL sergantiems pacientams buvo nustatytas didesnis MPV, kritinė MPV reikšmė - 8,55 fl. MPV reikšmei esant 8,55 fl, rodiklio jautrumas PAL nustatymui buvo 76%, o specifiškumas – 61%.

      3293
  • journal article;
    Lietuvos bendrosios praktikos gydytojas. Kaunas : Vitae Litera, 2017, t. 21, Nr. 2., 2017-03-13, p. 122-125.

    Mezenterinis panikulitas (MP) – reta patologija, apibūdinama kaip lėtinis, nespecifinis žarnyno pasaito riebalinio audinio uždegimas. Ligos paplitimas – 0,16-2,5 proc. Vyrams ši patologija dažnesnė nei moterims, santykis – 2-3:1. Pagrindinis patogeninis mechanizmas yra nespecifinis uždegiminis atsakas į skirtingus etiologiniuis faktorius, tačiau tikslios priežastys iki šiol nepakankamai ištirtos. Histologiškai išskiriamos trys ligos progresavimo stadijos. Dažniausiai ši liga yra besimptomė ir nustatoma atsitiktinai, kitais atvejais simptomai būna nespecifiniai ir kintami. Kompiuterinė tomografija yra pagrindinis tyrimas MP diagnozei nustatyti. Tiksliai diagnozei patvirtinti reikalinga ekscizinė biopsija ir histologinis tyrimas. Nėra visuotinai priimto sutarimo, kokį gydymą skirti, rekomenduojama gydyti imunomoduliatoriais, priešuždegiminiais, antifibrotiniais vaistais. Chirurginis gydymas gali būti taikomas, jei konservatyvusis gydymas neveiksmingas arba yra gyvybei pavojingų komplikacijų.

      3104
  • book; ;
    Tutkuvienė, Janina
    ;
    ; ; ; ; ;
    Schumacher, Gert Horst
    Kaunas : Lietuvos sveikatos mokslų universiteto Leidybos namai, 2016., 2016-10-02

    Vadovėlyje "Žmogaus anatomija" aprašoma žmogaus išorinė ir vidinė sandara organų sistemų, vykdančių organizmo kraujo ir limfos apykaitą, imuninę apsaugą, nervinę ir endokrininę reguliaciją, pateikiama organų raidos schema, pabrėžiama anatominių savitumų medicininė reikšmė. Vadovėlis skiriamas biomedicinos krypties medicinos ir odontologijos studijoms, juo galės naudotis ir rezidentai, doktorantai ir kiti specialistai. Vilniaus ir Kauno medicinos anatomai, 2003 m. rekomendavus LR švietimo ir mokslo ministerijos Aukštųjų mokyklų bendrųjų vadovėlių leidybos komisijai, parengė dviejų dalių vadovėlį „Žmogaus anatomija". Antroji jo dalis, parengta Kauno anatomų, padedant Vilniaus anatomei prof. Janinai Tutkuvienei, buvo išleista 2007 m., o pataisyta 2-oji laida - 2008 m. Šioje dalyje pateiktos anatomijos žinios apie organų sistemas, vykdančias organizmo kraujo ir limfos apykaitą, imuninę apsaugą, nervinę ir endokrininę reguliaciją, apie jutimo organus ir odą. Į šio vadovėlio autorių sąrašą taip pat buvo įtrauktas vokiečių anatomas Gertas-Horstas Šumacheris, leidęs vartoti kai kurias jo anatomijos vadovėlio iliustracijas.Sudėvėti vadovėlio egzemplioriai skaityklose ir jų dingimas knygynų lentynose rodo, kad jis turėjo paklausą, buvo naudingas siekiantiems anatomijos žinių žmonėms. Autoriams malonu tai žinoti ir esame dėkingi LSMULeidybos namams, sumaniusiems išleisti dar vieną jo laidą. Tad atsirado gera proga šioje laidoje, iš esmės nekeičiant vadovėlio dalykinio turinio, atlikti kai kuriuos pataisymus, papildymus ir jo sandaros pakeitimus. Pirmiausia buvo ištaisytos pačių autorių ir skaitytojų pastebėtos techninės ir dalykinės klaidos, koreguoti kai kurie lietuviški anatomijos terminai, atnaujinta bei išplėsta lietuviškų ir lotyniškų terminų rodyklė. Kai kurie skyriai papildyti aprašomų organų ontogenezės,

      3062  226
Most downloaded
Most WOS cited
  • journal article
    Patterson, Chris C
    ;
    Dahlquist, Gisela
    ;
    Harjutsalo, V
    ;
    Joner, Geir
    ;
    Feltbower, Richard G
    ;
    Svensson, Jannet
    ;
    Schober, Edith
    ;
    Gyürüs, Eva
    ;
    Castell, Conxa
    ;
    ;
    Rosenbauer, Joachim
    ;
    Iotova, Violeta
    ;
    Thorsson, Arni V
    ;
    Soltesz, Gyula
    Diabetologia. Berlin : Springer, 2007, vol. 50, no. 12., 2007-08-07, p. 2439-2442.

    Aims/hypothesis The aims of this study were to provide a contemporary picture of mortality and causes of death in Europe following a diagnosis of type 1 diabetes made before the 15th birthday, and to examine excess mortality by country for possible links to incidence level or national prosperity. Methods Thirteen population-based EURODIAB registers in 12 countries followed-up 28,887 children diagnosed since 1989, either by record linkage to population registers or through contact with doctors providing care. Results There were 141 deaths in the cohort during 219,061 person-years of follow-up compared with 69.1 deaths expected from national mortality rates, a standardised mortality ratio (SMR) of 2.0 (95% CI 1.7–2.4). The SMR varied from 0 to 4.7 between countries, but showed little relationship with the country’s incidence rate or gross domestic product (US$ per capita). The SMR did not change significantly with attained age, calendar period or time since diagnosis. The female SMR (2.7; 95% CI 2.0–3.5) was greater than the male SMR (1.8; 95% CI 1.4–2.2), although absolute numbers of excess deaths were similar in the two sexes. One-third of deaths were classified as directly attributable to diabetes (many with mention of ketoacidosis) and half were unrelated to diabetes. There was a non-significant excess of accidental/violent deaths (48 observed vs 40.7 expected; SMR 1.2; 95% CI 0.9–1.6) but little excess in suicides (11 observed, 10.2 expected; SMR 1.1; 95% CI 0.5–1.9). Conclusions/interpretation Before the onset of late complications, significant excess mortality existed following the diagnosis of type 1 diabetes in childhood, even in recent years. Variation between countries in this excess could not be explained. Electronic supplementary material The online version of this article (doi:10.1007/s00125-007-0824-8) contains supplementary material, which is available to authorised users.

      5
  • conference paper; ;
    Šmidt, A.
    Уcпexи гeпaтoлoгии. Pига, 1971., p. 292-310.
      5
  • conference paper
    Saunoriūtė, Sandra
    ;
    ; ;
    63rd International conference for students of physics and natural sciences Open Readings 2020 : 17-20 March 2020, Vilnius, Lithuania : abstract book / Faculty of Physics. Vilnius University. Vilnius : Vilnius University, 2020. ISBN 9786090703779., 2020-03-17, p. 507-507

    Chemical analysis of spice, aromatic plants at different vegetation stages can serve for the optimal collection of plant raw material revealing the period when the plant possesses the highest biological activity and accumulates the highest content of biologically active compounds, which could be used in pharmacy, medicine, food or cosmetic industry [1]. The aim of this study was to investigate the qualitative and quantitative composition of essential oils obtained from A. absinthium during different vegetation stages. The object of investigation was Artemisia absinthium L. a perennial medicinal, aromatic plant of Asteraceae (Bercht. & J. Presl) family. A. absinthium is widely used in the Lithuanian folk medicine mainly for stomachic and anthelmintic activity, also for healing gall-bladder and kidneys diseases, against insomnia, diarrhea [3, 5, 6, 7]. Raw material of A. absinthium was collected during different vegetation stages of vegetation cycle in Spice − Melliferous plants collection ex situ of Botanical Garden at Vytautas Magnus University in 2018. Five stages have been separated: growth and leaf production, flower bud development, beginning of the flowering, massive flowering, end of the flowering [4]. The essential oils have been extracted by hydrodistillation method and analysed by the chromatographic techniques in the gas phase and chromatography in gas phase coupled with mass spectrometry (GC/MS) so as to determine their chemical composition. The percentage composition of the essential oils was computed from GC peak areas without correction factors. Qualitative analysis was based on a comparison of retention times, indexes and mass spectra with the corresponding data in the literature [2] and computer mass spectra libraries. There were studied 5 samples of A. absinthium considering different vegetation stages. A total of 81 different compounds were found in the essential oils. The data showed the...[...].

      7
  • conference paper;
    Matulis, Daumantas
    ;
    Vita Scientia : International conference „Vita Scientia“ : conference book : 3rd January, 2018, Vilnius / Vilnius University. Vilnius : Vita est Scientia, 2018, 2018., 2018-01-03, p. 53-54

    Heat shock protein 90 (Hsp90) is a molecular chaperone with over 200 identified client proteins. This chaperone protein is crucial for protein folding and stabillization and interfere in many pathways of cancer cells, therefore it is a potential target for anticancer therapy. Hsp90 inhibitors bind to the N-terminal ATP domain of Hsp90, and several of them have entered clinical trials. Recent studies show that Hsp90 inhibitors in combination with clinically used chemotherapeutic agents may act synergistically, therefore such effect can reduce the dose and toxicity of used drugs, and minimize or delay the induction of drug resistance [1]. The aim of our study was to evaluate activity of different combinations of two Hsp90 inhibitors (ICPD47 and ICPD62) and three anticancer agents (gemcitabine, 5fluorouracil and doxorubicin) against pancreatic cancer cells. The effect of Hsp90 inhibitors, other agents and different combinations on cell viability was evaluated by MTT assay in two pancreatic cancer cell lines: MIA PaCa-2 and Panc-1. The type of combination effect was determined by calculating combination index (CI), using CompuSyn software based on Chou-Talalay method [2]. Synergism was considered when CI < 1, antagonism when CI > 1, and CI value of 1 defined an additive effect of the drug combination. Results. Among tested Hsp90 inhibitors ICPD62 had the greatest effect on cell viability (EC50 values after 72 h on MIA PaCa-2 and Panc-1 were 0.446 ± 0.06 µM and 0.41 ± 0.08 µM, respectively) and among other anticancer agents doxorubicin showed the greatest effect on cell viability (EC50 values after 72 h on MIA PaCa-2 and Panc-1 were 0.076 ± 0.03 µM and 0.074 ± 0.02 µM, respectively). The combination of ICPD47 and gemcitabine with concentration ratio 5:1, showed the greatest synergistic activity in MIA PaCa-2 cell line (CI = 0.192, when fa = 0.5), and the combination of ICPD62 and gemcitabine with concentration rat[...].

      10
  • research article
    Теория и практика автоматизации в кардиологии : [тематический сборник научных трудов ИБС] / [Редкол.: З.И. Янушкевичус (отв. ред.) и др.] ; Министерство высшего и среднего специального образования Литовской ССР. Научно-исследовательский институт физиологии и патологии сердечно-сосудистой системы при Каунасском медицинском институте. Вильнюс : Редакционно-издательский совет М-во высш. и сред. спец. образования ЛитССР, 1980., p. 3-11.

    Распространение сердечно-сосудистых заболеваний и расширение объема борьбы с ними обусловило значительное увеличение масштабов обследования населения. Обработка этих данных, обязательно включающих электрокардиологические показатели, уже невозможна без применения математических методов и вычислительной техники. Первые работы по применению ЭВМ для анализа электрокардиограмм (ЭКГ) появились в конце пятидесятых годов, а в начале шестидесятых – первые экспериментальные системы анализа ЭКГ, промышленный выпуск которых начался в конце шестидесятых годов в США. По данным Кейсерс, только в США в 1970 году около 50 фирм м компаний занимались разработкой и распространением систем компьютерного анализа ЭКГ. По данным Rautaharju, в настоящее время в капиталистических странах действуют по крайней мере 20 больших центров комьютерного анализа ЭКГ, которые в 1976 году проанализировали около 5 миллионов ЭКГ, в том числе фирмы IBM и Telemed по 1 миллиону 400 тысяч ЭКГ, фирма Hewlett-Packard – 600.000 ЭКГ. [...].

      5
Most SCOPUS cited
  • journal article
    Patterson, Chris C
    ;
    Dahlquist, Gisela
    ;
    Harjutsalo, V
    ;
    Joner, Geir
    ;
    Feltbower, Richard G
    ;
    Svensson, Jannet
    ;
    Schober, Edith
    ;
    Gyürüs, Eva
    ;
    Castell, Conxa
    ;
    ;
    Rosenbauer, Joachim
    ;
    Iotova, Violeta
    ;
    Thorsson, Arni V
    ;
    Soltesz, Gyula
    Diabetologia. Berlin : Springer, 2007, vol. 50, no. 12., 2007-08-07, p. 2439-2442.

    Aims/hypothesis The aims of this study were to provide a contemporary picture of mortality and causes of death in Europe following a diagnosis of type 1 diabetes made before the 15th birthday, and to examine excess mortality by country for possible links to incidence level or national prosperity. Methods Thirteen population-based EURODIAB registers in 12 countries followed-up 28,887 children diagnosed since 1989, either by record linkage to population registers or through contact with doctors providing care. Results There were 141 deaths in the cohort during 219,061 person-years of follow-up compared with 69.1 deaths expected from national mortality rates, a standardised mortality ratio (SMR) of 2.0 (95% CI 1.7–2.4). The SMR varied from 0 to 4.7 between countries, but showed little relationship with the country’s incidence rate or gross domestic product (US$ per capita). The SMR did not change significantly with attained age, calendar period or time since diagnosis. The female SMR (2.7; 95% CI 2.0–3.5) was greater than the male SMR (1.8; 95% CI 1.4–2.2), although absolute numbers of excess deaths were similar in the two sexes. One-third of deaths were classified as directly attributable to diabetes (many with mention of ketoacidosis) and half were unrelated to diabetes. There was a non-significant excess of accidental/violent deaths (48 observed vs 40.7 expected; SMR 1.2; 95% CI 0.9–1.6) but little excess in suicides (11 observed, 10.2 expected; SMR 1.1; 95% CI 0.5–1.9). Conclusions/interpretation Before the onset of late complications, significant excess mortality existed following the diagnosis of type 1 diabetes in childhood, even in recent years. Variation between countries in this excess could not be explained. Electronic supplementary material The online version of this article (doi:10.1007/s00125-007-0824-8) contains supplementary material, which is available to authorised users.

      5
  • conference paper; ;
    Šmidt, A.
    Уcпexи гeпaтoлoгии. Pига, 1971., p. 292-310.
      5
  • conference paper
    Saunoriūtė, Sandra
    ;
    ; ;
    63rd International conference for students of physics and natural sciences Open Readings 2020 : 17-20 March 2020, Vilnius, Lithuania : abstract book / Faculty of Physics. Vilnius University. Vilnius : Vilnius University, 2020. ISBN 9786090703779., 2020-03-17, p. 507-507

    Chemical analysis of spice, aromatic plants at different vegetation stages can serve for the optimal collection of plant raw material revealing the period when the plant possesses the highest biological activity and accumulates the highest content of biologically active compounds, which could be used in pharmacy, medicine, food or cosmetic industry [1]. The aim of this study was to investigate the qualitative and quantitative composition of essential oils obtained from A. absinthium during different vegetation stages. The object of investigation was Artemisia absinthium L. a perennial medicinal, aromatic plant of Asteraceae (Bercht. & J. Presl) family. A. absinthium is widely used in the Lithuanian folk medicine mainly for stomachic and anthelmintic activity, also for healing gall-bladder and kidneys diseases, against insomnia, diarrhea [3, 5, 6, 7]. Raw material of A. absinthium was collected during different vegetation stages of vegetation cycle in Spice − Melliferous plants collection ex situ of Botanical Garden at Vytautas Magnus University in 2018. Five stages have been separated: growth and leaf production, flower bud development, beginning of the flowering, massive flowering, end of the flowering [4]. The essential oils have been extracted by hydrodistillation method and analysed by the chromatographic techniques in the gas phase and chromatography in gas phase coupled with mass spectrometry (GC/MS) so as to determine their chemical composition. The percentage composition of the essential oils was computed from GC peak areas without correction factors. Qualitative analysis was based on a comparison of retention times, indexes and mass spectra with the corresponding data in the literature [2] and computer mass spectra libraries. There were studied 5 samples of A. absinthium considering different vegetation stages. A total of 81 different compounds were found in the essential oils. The data showed the...[...].

      7
  • conference paper;
    Matulis, Daumantas
    ;
    Vita Scientia : International conference „Vita Scientia“ : conference book : 3rd January, 2018, Vilnius / Vilnius University. Vilnius : Vita est Scientia, 2018, 2018., 2018-01-03, p. 53-54

    Heat shock protein 90 (Hsp90) is a molecular chaperone with over 200 identified client proteins. This chaperone protein is crucial for protein folding and stabillization and interfere in many pathways of cancer cells, therefore it is a potential target for anticancer therapy. Hsp90 inhibitors bind to the N-terminal ATP domain of Hsp90, and several of them have entered clinical trials. Recent studies show that Hsp90 inhibitors in combination with clinically used chemotherapeutic agents may act synergistically, therefore such effect can reduce the dose and toxicity of used drugs, and minimize or delay the induction of drug resistance [1]. The aim of our study was to evaluate activity of different combinations of two Hsp90 inhibitors (ICPD47 and ICPD62) and three anticancer agents (gemcitabine, 5fluorouracil and doxorubicin) against pancreatic cancer cells. The effect of Hsp90 inhibitors, other agents and different combinations on cell viability was evaluated by MTT assay in two pancreatic cancer cell lines: MIA PaCa-2 and Panc-1. The type of combination effect was determined by calculating combination index (CI), using CompuSyn software based on Chou-Talalay method [2]. Synergism was considered when CI < 1, antagonism when CI > 1, and CI value of 1 defined an additive effect of the drug combination. Results. Among tested Hsp90 inhibitors ICPD62 had the greatest effect on cell viability (EC50 values after 72 h on MIA PaCa-2 and Panc-1 were 0.446 ± 0.06 µM and 0.41 ± 0.08 µM, respectively) and among other anticancer agents doxorubicin showed the greatest effect on cell viability (EC50 values after 72 h on MIA PaCa-2 and Panc-1 were 0.076 ± 0.03 µM and 0.074 ± 0.02 µM, respectively). The combination of ICPD47 and gemcitabine with concentration ratio 5:1, showed the greatest synergistic activity in MIA PaCa-2 cell line (CI = 0.192, when fa = 0.5), and the combination of ICPD62 and gemcitabine with concentration rat[...].

      10
  • research article
    Теория и практика автоматизации в кардиологии : [тематический сборник научных трудов ИБС] / [Редкол.: З.И. Янушкевичус (отв. ред.) и др.] ; Министерство высшего и среднего специального образования Литовской ССР. Научно-исследовательский институт физиологии и патологии сердечно-сосудистой системы при Каунасском медицинском институте. Вильнюс : Редакционно-издательский совет М-во высш. и сред. спец. образования ЛитССР, 1980., p. 3-11.

    Распространение сердечно-сосудистых заболеваний и расширение объема борьбы с ними обусловило значительное увеличение масштабов обследования населения. Обработка этих данных, обязательно включающих электрокардиологические показатели, уже невозможна без применения математических методов и вычислительной техники. Первые работы по применению ЭВМ для анализа электрокардиограмм (ЭКГ) появились в конце пятидесятых годов, а в начале шестидесятых – первые экспериментальные системы анализа ЭКГ, промышленный выпуск которых начался в конце шестидесятых годов в США. По данным Кейсерс, только в США в 1970 году около 50 фирм м компаний занимались разработкой и распространением систем компьютерного анализа ЭКГ. По данным Rautaharju, в настоящее время в капиталистических странах действуют по крайней мере 20 больших центров комьютерного анализа ЭКГ, которые в 1976 году проанализировали около 5 миллионов ЭКГ, в том числе фирмы IBM и Telemed по 1 миллиону 400 тысяч ЭКГ, фирма Hewlett-Packard – 600.000 ЭКГ. [...].

      5

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