{"id":125795,"date":"2025-07-01T10:33:56","date_gmt":"2025-07-01T07:33:56","guid":{"rendered":"https:\/\/lsmu.lt\/?page_id=125795"},"modified":"2026-04-13T15:37:36","modified_gmt":"2026-04-13T12:37:36","slug":"personalized-disease-prediction-and-prevention-in-chronic-inflammatory-disorders","status":"publish","type":"page","link":"https:\/\/lsmu.lt\/en\/research-and-innovations\/projects\/international-projects\/personalized-disease-prediction-and-prevention-in-chronic-inflammatory-disorders\/","title":{"rendered":"Personalized disease prediction and prevention in chronic inflammatory disorders"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n<\/div>\n<\/div>\n\n<div class=\"container\">\n\n\t<div class=\"md:grid md:grid-cols-2 md:gap-x-8 mt-2 mb-10\">\n\n\t\t\t\n\t\t\t\t<div class=\"prose md:prose-lg\">\n\t\t\t\t\t<ul class=\"wp-block-list\">\n<li><strong>Project No.<\/strong>: 101156542<\/li>\n<li><strong>Project acronym: <\/strong>PerPrev-CID<\/li>\n<li><strong>Principal investigator (LSMU):<\/strong> Jurgita Skiecevi\u010dien\u0117<\/li>\n<li><strong>Project coordinator: <\/strong>Universitatsklinikum Schleswig-Holstein (UKSH), Germany<\/li>\n<\/ul>\n\t\t\t\t<\/div>\n\n        \n\t\t\t\t<div class=\"prose md:prose-lg\">\n\t\t\t\t\t<ul class=\"wp-block-list\">\n<li><strong>Total project value:<\/strong> 11 000 246,75 Euro<\/li>\n<li><strong>Part of the project value allocated to the LSMU: <\/strong>578 538,75 Euro<\/li>\n<li><strong>Project duration:<\/strong> from 2025-01-01 to 2029-12-31<\/li>\n<li><strong>Funding programme:<\/strong> Horizon Europe<\/li>\n<li><strong>Project website: <\/strong><a href=\"https:\/\/www.perprev-cid.eu\/\" target=\"_blank\" rel=\"noopener\">www.perprev-cid.eu<\/a><\/li>\n<\/ul>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- \/wp:list --><\/p>\n\t\t\t\t<\/div>\n\n        \t<\/div>\n<\/div>\n\n<div class=\"container\">\n\t<div class=\"prose md:prose-lg\">\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Background<\/strong>: Chronic inflammatory diseases (CID) are a group of non-communicable disorders of the immune system with a lifetime prevalence of over 10% in the EU. Rheumatoid arthritis (RA) and inflammatory bowel diseases (IBD) are two archetypal CIDs with a particularly high unmet medical need and impact on European health care systems. Objectives: The PerPrev-CID consortium aims to set up new standards for decision support tool development for preventive and early therapeutic interventions in RA and IBD. Selected main aims are: (i) To define actionable predictors from longitudinal multi-level Omics and clinical data integration In RA and IBD. We will identify markers indicating progression from pre-symptomatic to manifest disease and signatures predicting early disease relapse (ii) To develop new tools for home-based and continuous assessment of patient-related data dimensions using digital health apps\/wearables, including more innovative, objective parameters, such as movement patterns, physical activity, and sleep. (iii) To assess the healthpromoting effects of interfering with the tryptophan pathway in a proof-of-concept nutritional study in early RA and IBD. (iv) To study ethical, legal and economic consequences of risk assessment and early low-threshold preventive interventions. Important aspects are the communication of the risk concept, economic implications of broad testing and interventions as well as patients\u00b4 perception of the concept of risk prediction. Expected impact: We will develop prototype solutions for privacy-preserving AI-based data analysis for research and clinical application and will test a first proof-of-concept low threshold intervention in RA and IBD. Our approaches will provide a clear health benefit to the citizens of the EU by improving health outcomes, empowering joint decision making and contributing to appropriate action plans to reduce the avoidable burden of the diseases.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><strong>The expected outcome of the project<\/strong><\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Implementation of an international systems medicine framework leveraging harmonized data management and explainable AI (XAI) alongside swarm-learning techniques, providing the optimal environment for biomarker discovery and validation<\/li>\n\n\n\n<li>Better understanding of molecular factors driving individual variation, resilience and disease risk<\/li>\n\n\n\n<li>Biomarkers and decision support tools that accurately estimate risks for disease onset<\/li>\n\n\n\n<li>Novel home-based tools and biomarkers that predict onset of disease flares<\/li>\n\n\n\n<li>Efficacy of nutritional interventions (FSMP) in preventing disease flares\/progression<\/li>\n\n\n\n<li>Personalized health engagement information package\u2022 Informed policy recommendations<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><em>Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.<\/em><\/p>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\" style=\"font-size:25px;font-style:normal;font-weight:700\"><summary><strong>P<\/strong>ROJECT PARTNERS<\/summary>\n<ul class=\"wp-block-list\">\n<li class=\"has-medium-font-size\">The University Of Manchester (Uom)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Universite De Liege (Uliege)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Weizmann Institute Of Science (Weizmann)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Lietuvos Sveitakos Mokslu Universiteto Ligonine Kauno Klinikos (Lsmuh)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Deutsches Zentrum Fur Neurodegenerative Erkrankungen Ev (Dzne)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Vib Vzw (Vib)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Stichting Radboud Universiteit (Ru)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Universita Cattolica Del Sacro Cuore (Ucsc)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Eurice European Research And Project Office Gmbh (Eurice)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">European Federation Of Crohn&#8217;s And Ulcerative ColitisAssociations (Efcca)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Universite De Geneve (Unige)<\/li>\n\n\n\n<li class=\"has-medium-font-size\">European Alliance Of Associations For Rheumatology (Eular)<\/li>\n<\/ul>\n<\/details>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<\/div>\n<\/div>\n\n<div class=\"container\">\n\t<div class=\"grid grid-cols-2 sm:grid-cols-3 md:grid-cols-4 lg:grid-cols-5 md:mt-12 mb-10 md:mb-10\">\n\t\t\t\t\t\t\t\t\t<div class=\"logo-item\" style=\"padding-bottom: 60%;\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" class=\"bg object-contain\" style=\"object-position: center;\" loading=\"lazy\" src=\"https:\/\/lsmu.lt\/wp-content\/uploads\/Perprev-cid.webp\" alt=\"\">\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t        \t\t\t\t\t\t<div class=\"logo-item\" style=\"padding-bottom: 60%;\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" class=\"bg object-contain\" style=\"object-position: center;\" loading=\"lazy\" src=\"https:\/\/lsmu.lt\/wp-content\/uploads\/EN-V-Funded-by-the-EU_PANTONE-3.jpg\" alt=\"\">\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t        \t<\/div>\n<\/div>\n\n<div class=\"container\">\n\t<div class=\"prose md:prose-lg\">\n","protected":false},"excerpt":{"rendered":"<p>Background: Chronic inflammatory diseases (CID) are a group of non-communicable disorders of the immune system with a lifetime prevalence of over 10% in the EU. Rheumatoid arthritis (RA) and inflammatory bowel diseases (IBD) are two archetypal CIDs with a particularly high unmet medical need and impact on European health care systems. Objectives: The PerPrev-CID consortium [&hellip;]<\/p>\n","protected":false},"author":35,"featured_media":0,"parent":86867,"menu_order":209,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-125795","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.1 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Personalized disease prediction and prevention in chronic inflammatory disorders - LSMU<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsmu.lt\/en\/research-and-innovations\/projects\/international-projects\/personalized-disease-prediction-and-prevention-in-chronic-inflammatory-disorders\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Personalized disease prediction and prevention in chronic inflammatory disorders\" \/>\n<meta property=\"og:description\" content=\"Background: Chronic inflammatory diseases (CID) are a group of non-communicable disorders of the immune system with a lifetime prevalence of over 10% in the EU. Rheumatoid arthritis (RA) and inflammatory bowel diseases (IBD) are two archetypal CIDs with a particularly high unmet medical need and impact on European health care systems. 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