{"id":53153,"date":"2023-03-08T11:58:08","date_gmt":"2023-03-08T09:58:08","guid":{"rendered":"https:\/\/lsmu.lt\/?page_id=53153"},"modified":"2023-03-08T14:06:03","modified_gmt":"2023-03-08T12:06:03","slug":"gut-blood-liver-axis","status":"publish","type":"page","link":"https:\/\/lsmu.lt\/en\/research-and-innovations\/projects\/gut-blood-liver-axis\/","title":{"rendered":"Gut -blood -liver axis"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Project<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Gut -blood -liver axis: Circulating microbiome as non -invasive biomarker for Inflammatory bowel disease (IBD) and Primary sclerosing cholangitis (PSC) [Blood-Biome]<\/strong><\/p>\n\n\n<\/div>\n<\/div>\n\n<div class=\"container\">\n\t\t\t\t<div class=\"lg:grid lg:grid-cols-12 mb-6 md:mb-12 lg:gap-4\">\n\t\t\t\t<div class=\"col-span-6 tablet:pb-12 mobile:pb-6 md:order-2\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"prose md:prose-lg\">\n\t\t\t\t\t\t\t<p><strong>Project contract no.:<\/strong>\u00a0 S-BMT-21-11 (LT08-2-LMT-K-01-060)<\/p>\n<p><strong>Start-end dates:<\/strong> 2021 01 01 \u2013 2023 12 31<\/p>\n<p><strong>Principal investigator:<\/strong> Prof. Habil. Dr. Gediminas Kiudelis<\/p>\n<p><strong>Project promoter:<\/strong>\u00a0Lithuanian university of Health Sciences<\/p>\n<p><strong>Project partners:<\/strong><br \/>\nOslo University Hospital (OUH), Norway<br \/>\nLatvian Biomedical Research and Study Centre (LBMC), Latvia<br \/>\nUniversity of Tartu (UTARTU), Estonia<\/p>\n<p><strong>Funding source:<\/strong>\u00a0Grant from Iceland, Liechtenstein and Norway through the European Economic Area (EEA) Financial Mechanisms 2014-2021.<\/p>\n<p><strong>Total budget:\u00a0<\/strong>999 990.35 Eur<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"col-span-6 md:order-1 my-auto\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"xl:-ml-36 xl:pl-2 lg:pr-10 \">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"940\" height=\"788\" src=\"https:\/\/lsmu.lt\/wp-content\/uploads\/iceland-lichtenstein-Norway-grants.png\" class=\"w-full\" alt=\"\" srcset=\"https:\/\/lsmu.lt\/wp-content\/uploads\/iceland-lichtenstein-Norway-grants.png 940w, https:\/\/lsmu.lt\/wp-content\/uploads\/iceland-lichtenstein-Norway-grants-300x251.png 300w, https:\/\/lsmu.lt\/wp-content\/uploads\/iceland-lichtenstein-Norway-grants-300x251@2x.png 600w\" sizes=\"auto, (max-width: 940px) 100vw, 940px\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t<\/div>\n\n<div class=\"container\">\n\t<div class=\"prose md:prose-lg\">\n\n\n\n<h2 class=\"wp-block-heading\">Summary:<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Gut microbiome has been shown to play a crucial role in ulcerative colitis (UC) and is impaired in a related extraintestinal autoimmune condition &#8211; primary sclerosing cholangitis (PSC). One of the consequences that are associated with chronic inflammation of the intestinal mucosa is increased intestinal permeability, the so-called \u201c<strong>leaky gut phenomenon<\/strong>\u201d, which might provoke bacterial translocation to the blood through the&nbsp;<strong>gut-blood-liver axis<\/strong>. Recently, it has been reported that a considerable amount and highly divergent bacterial traces can be found in human blood samples; however, circulating blood microbiome and its diagnostic potential has not been previously investigated in UC and PSC. Therefore, in this project,&nbsp;<strong>a multidisciplinary research team composed of clinicians, molecular biologists and biostatisticians from<\/strong><strong>Norway and Baltic countries&nbsp;<\/strong>will aim to&nbsp;<strong>determine circulating blood microbiome signatures in UC and related autoimmune liver<\/strong><strong>disease &#8211; PSC.&nbsp;<\/strong>This aim will be achieved through the use of very well-defined large patient cohorts, advanced metagenomic sequencing techniques, and bioinformatical analysis. In addition, with the use of a germ-free UC mice model, mechanistic insights of bacterial transfer to the blood circulation will be evaluated. The project will generate clinically relevant data on the diagnostic and prognostic value of the specific circulating blood microbiota profiles, that could benefit to the&nbsp;<strong>generation of new non-invasive tools&nbsp;<\/strong>in the&nbsp;<strong>personalized management&nbsp;<\/strong>of UC and PSC. The study&nbsp;<strong>team will merge existing know-how, equipment and biobank resources across four different countries&nbsp;<\/strong>in order to&nbsp;<strong>enable the transfer of knowledge across different institutions&nbsp;<\/strong>and&nbsp;<strong>promote the training of young scientists&nbsp;<\/strong>and&nbsp;<strong>future collaborations<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"553\" src=\"https:\/\/lsmu.lt\/wp-content\/uploads\/Baltijos_saliu_study_design_EN-1-1024x553.jpeg\" alt=\"\" class=\"wp-image-53202\" srcset=\"https:\/\/lsmu.lt\/wp-content\/uploads\/Baltijos_saliu_study_design_EN-1-1024x553.jpeg 1024w, https:\/\/lsmu.lt\/wp-content\/uploads\/Baltijos_saliu_study_design_EN-1-300x162.jpeg 300w, https:\/\/lsmu.lt\/wp-content\/uploads\/Baltijos_saliu_study_design_EN-1-1536x829.jpeg 1536w, https:\/\/lsmu.lt\/wp-content\/uploads\/Baltijos_saliu_study_design_EN-1.jpeg 2000w, https:\/\/lsmu.lt\/wp-content\/uploads\/Baltijos_saliu_study_design_EN-1-300x162@2x.jpeg 600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Project Gut -blood -liver axis: Circulating microbiome as non -invasive biomarker for Inflammatory bowel disease (IBD) and Primary sclerosing cholangitis (PSC) [Blood-Biome] Summary: Gut microbiome has been shown to play a crucial role in ulcerative colitis (UC) and is impaired in a related extraintestinal autoimmune condition &#8211; primary sclerosing cholangitis (PSC). One of the consequences [&hellip;]<\/p>\n","protected":false},"author":51,"featured_media":0,"parent":23446,"menu_order":419,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-53153","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.1 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Gut -blood -liver axis - LSMU<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsmu.lt\/en\/research-and-innovations\/projects\/gut-blood-liver-axis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gut -blood -liver axis\" \/>\n<meta property=\"og:description\" content=\"Project Gut -blood -liver axis: Circulating microbiome as non -invasive biomarker for Inflammatory bowel disease (IBD) and Primary sclerosing cholangitis (PSC) [Blood-Biome] Summary: Gut microbiome has been shown to play a crucial role in ulcerative colitis (UC) and is impaired in a related extraintestinal autoimmune condition &#8211; primary sclerosing cholangitis (PSC). 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