Lithuanian University of Health Sciences Research Management System (CRIS)





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  • research article; ; ;
    Medicina, 2025-04-04, vol. 61, no. 4, p. 1-11

    Background and Objectives: Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a well-established technique for evaluating myocardial perfusion and function in patients with suspected or known coronary artery disease. While conventional dual-detector SPECT scanners have limitations in spatial resolution and photon detection sensitivity, recent advancements, including full-ring solid-state cadmium zinc telluride (CZT) detectors, offer enhanced image quality and improved diagnostic accuracy. This study aimed to compare the performance of Veriton-CT, a full-ring CZT SPECT system, with GE Discovery 530c, a dedicated cardiac fixed-angle gamma camera, in myocardial perfusion imaging and their correlation with coronary angiography findings. Materials and Methods: This was a prospective study that analyzed 21 patients who underwent MPI at the Department of Nuclear Medicine, Lithuanian University of Health Sciences, Kauno Klinikos. A one-day stress–rest protocol using 99mTc-Sestamibi was employed, with stress testing performed via bicycle ergometry or pharmacological induction. MPI was first conducted using GE Discovery 530c (GE Health Care, Boston, MA, USA), followed by imaging on Veriton-CT, which included low-dose CT for attenuation correction. The summed stress score (SSS), summed rest score (SRS), and summed difference score (SDS) were analyzed and compared between both imaging modalities. Coronary angiography results were retrospectively collected, and lesion-based analysis was performed to assess the correlation between imaging results and the presence of significant coronary artery stenosis (≥35% and ≥70% narrowing). Image quality and the certainty of distinguishing the inferior myocardial wall from extracardiac structures were also evaluated by two independent researchers with differing levels of experience. Results: Among the 14 patients included in the final analysis, Veriton-CT was more likely to classify MPI scans as normal (64.3%) compared to GE Discovery 530c (28.6%). Additionally, Veriton-CT provided a better assessment of the right coronary artery (RCA) basin, showing greater agreement with coronary angiography findings than GE Discovery 530c, although the difference was not statistically significant. No significant differences in lesion overlap were observed for the left anterior descending artery (LAD) or left circumflex artery (LCx) basins. Furthermore, the image quality assessment revealed slightly better delineation of extracardiac structures using Veriton-CT (Spectrum Dynamics Medical, Caesarea, Israel), particularly when evaluated by an experienced researcher. However, no significant difference was observed when assessed by a less experienced observer. Conclusions: Our findings suggest that Veriton-CT, with its full-ring CZT detector system, may offer advantages over fixed-angle gamma cameras in improving image quality and reducing attenuation artifacts in MPI. Although the difference in correlations with coronary angiography findings was not statistically significant, Veriton-CT showed a trend toward better agreement, particularly in the RCA basin. These results indicate that full-ring SPECT imaging could improve the diagnostic accuracy of non-invasive MPI, potentially reducing the need for unnecessary invasive angiography. Further studies with larger patient cohorts are required to confirm these findings and evaluate the clinical impact of full-ring SPECT technology in myocardial perfusion imaging.

  • Kraujas piene - aktuali, ekonomiškai skausminga problema, su kuria susiduria pienininkystės ūkiai. Keli litrai pieno su krauju gali sugadinti visą šaldytuve esantį pieną. Kodėl į pieną patenka kraujo? Hipotezių yra įvairių, jas kėlėme analizuodami konkretų atvejį.

  • journal article;
    Mano ūkis, 2025-04-03, no. 4, p. 53-55

    Maždaug prieš 15 metų Lietuvai pavyko išvengti daugelyje Europos šalių siautėjusio mėlynojo liežuvio ligos (MLL) 8-ojo serotipo protrūkio, kuris sukėlė milžiniškus nuostolius galvijų ir avių ūkiuose. dabar mums gali taip nepasisekti.

  • preprint
    Global Cardiovascular Risk Consortium
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    Magnussen, Christina
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    Alegre-Diaz, Jesus
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    Al-Nasser, Lubna A
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    Amouyel, Philippe
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    Aviles-Santa, Larissa
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    Bakker, Stephan J L
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    Ballantyne, Christie M
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    Bernabé-Ortiz, Antonio
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    Bobak, Martin
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    Boffetta, Paolo
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    Brenner, Hermann
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    Brunström, Mattias
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    Can, Gunay
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    Carrillo-Larco, Rodrigo M
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    Checkley, William
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    Dallongeville, Jean
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    De Bacquer, Dirk
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    de Gaetano, Giovanni
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    de Lemos, James A
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    di Carluccio, Eleonora
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    Dobson, Annette
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    Donfrancesco, Chiara
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    Dörr, Marcus
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    d'Orsi, Eleonora
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    Drygas, Wojciech
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    Dullaart, Robin P F
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    Engström, Gunnar
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    Ferrario, Marco M
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    Ferrières, Jean
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    Figtree, Gemma A
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    Gaye, Bamba
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    Ghayour-Mobarhan, Majid
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    Goldbourt, Uri
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    Gonzalez, Clicerio
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    Gossling, Alina
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    Grassi, Guido
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    Gupta, Prakash C
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    He, Jiang
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    Hodge, Allison M
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    Hozawa, Atsushi
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    Hveem, Kristian
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    Iacoviello, Licia
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    Ikram, M Kamran
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    Inoue, Manami
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    Irazola, Vilma
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    Jobe, Modou
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    Jousilahti, Pekka
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    Kaleebu, Pontiano
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    Kavousi, Maryam
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    Kee, Frank
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    Khalili, Davood
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    Klotsche, Jens
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    Koenig, Wolfgang
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    Kontsevaya, Anna
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    Kowlessur, Sudhirsen
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    Kuri-Morales, Pablo
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    Kuulasmaa, Kari
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    Kweon, Sun-Seog
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    Lackner, Karl J
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    Landmesser, Ulf
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    Leistner, David M
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    Leiva Sisnieguez, Carlos E
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    Leong, Darryl
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    Lind, Lars
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    Linneberg, Allan
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    Lorenz, Thiess
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    Lyngbakken, Magnus N
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    Malekzadeh, Reza
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    Malyutina, Sofia
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    Mathiesen, Ellisiv B
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    McElduff, Patrick
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    Melander, Olle
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    Metspalu, Andres
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    Miranda, J Jaime
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    Moitry, Marie
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    Mugisha, Joseph
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    Munzinger, Julia
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    Nalini, Mahdi
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    Nambi, Vijay
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    Nilsson, Peter M
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    Ninomiya, Toshiharu
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    Omland, Torbjørn
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    Ong, Sok King
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    Oppermann, Karen
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    Pajak, Andrzej
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    Palmieri, Luigi
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    Panagiotakos, Demosthenes
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    Park, Sue K
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    Pednekar, Mangesh S
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    Perianayagam, Arokiasamy
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    Peters, Annette
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    Poustchi, Hossein
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    Prabhakaran, Dorairaj
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    Prentice, Andrew M
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    Prescott, Eva
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    Quyyumi, Arshed
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    Risérus, Ulf
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    Sakata, Satoko
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    Salazar, Martin
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    Salomaa, Veikko
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    Sans, Susana
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    Sattler, E Lilian P
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    Schöttker, Ben
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    Schutte, Aletta E
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    Sepanlou, Sadaf G
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    Sharma, Sanjib K
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    Shaw, Jonathan
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    Simons, Leon A
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    Söderberg, Stefan
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    Tapia-Conyer, Roberto
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    Thorand, Barbara
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    Tunstall-Pedoe, Hugh
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    Tuomilehto, Jaakko
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    Twerenbold, Raphael
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    Vanuzzo, Diego
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    Veronesi, Giovanni
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    Wannamethee, S Goya
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    Watanabe, Masafumi
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    Weimann, Jessica
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    Wild, Philipp S
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    Yao, Yao
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    Zeng, Yi
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    Ziegler, Andreas
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    Ojeda, Francisco M
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    Blankenberg, Stefan
    The New England Journal of Medicine, 2025-03-30, vol. 00, no. 00, p. 1-14

    Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear.

  • research article; ; ;
    Medicina, 2025-04-02, vol. 61, no. 4, p. 1-13

    Background and Objectives: Alcohol consumption has been a longstanding public health concern and known link to violence. The aims of this study were to analyze alcohol-related homicide cases in Lithuania, focusing on the prevalence of binge drinking among perpetrators and victims, the situational and behavioral patterns leading to violence, and the legal outcomes of these cases. Materials and Methods: This study employed a retrospective analysis of court case law of criminal cases of the year 2019. The analysis was conducted by combining qualitative and quantitative analytical approaches. Results: The findings revealed that 84.6% of homicides occurred during binge drinking events. Alcohol intoxication was prevalent among both perpetrators (92.3%) and victims (86.5%), emphasizing the dual role of alcohol in homicide cases. Interpersonal violence was the primary pattern of homicide (78.8%), while planned homicides accounted for 21.2%. Thematic content analysis of the cases revealed that Lithuanian courts consistently regard alcohol consumption as an aggravating factor that contributes to the commission of violent crimes and influences the severity of criminal punishment. This reflects a judicial position that voluntary intoxication does not lessen legal responsibility, despite its effects on impairing judgment, heightening aggression and impulsivity, and escalating conflicts into deadly violence. Conclusions: Our findings revealed that the majority of alcohol-involved homicides occurred during binge drinking events, in a domestic environment, and because of unplanned acts of interpersonal violence. Targeted public health interventions should focus on strengthening alcohol control policies and enforcing stricter regulations to discourage binge drinking environments.

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    Stankutė, Deimantė
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    Kavaliauskaitė, Agnė
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  • journal article
    Lietuvos bendrosios praktikos gydytojas. Kaunas : Vitae Litera, 2008, t. 12, Nr. 10., p. 679-681.

    Lėtinis atrofinis gastritas – tai ilgalaikio lėtinio skrandžio uždegimo sąlygota skrandžio gleivinės atrofija. Atrofinio gastrito fone vystosi metaplazija žarninio tipo epiteliu, vėliau epitelio displazija ir skrandžio vėžys. Atrofija ir žarninė metaplazija apibūdinamos kaip ikivėžinės būklės. Skrandžio gleivinės atrofija ir žarninė metaplazija yra dažnesnės šalyse, kuriose yra didelis sergamumas skrandžio vėžiu. Atrofinis gastritas laikomas ikivėžine liga, tačiau nėra visiškai aišku, ar galimas atrofijos proceso sustabdymas, ar tai leidžia apsaugoti nuo skrandžio vėžio.

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