Lithuanian University of Health Sciences Research Management System (CRIS)





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  • journal-article
    Liobikienė, Genovaitė
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    Cleaner and Responsible Consumption, 2025-03-01, vol. 16, p. 1-9

    The war in Ukraine triggered a big energy crisis, which particularly escalated in the winter of 2023 throughout all Europe. The crisis was a good opportunity for policymakers to encourage people to save electricity in the household. The aim of this paper is to analyse the changes in electricity saving behaviour and electricity consumption in Lithuania comparing the periods of the month preceding the war in Ukraine in 2022 and the peak of the energy crisis, which occurred in the winter of 2023. Furthermore, the paper examines how the attitudes related to the war influenced these behaviours. The results revealed that since the beginning of the war the level of electricity saving behaviour and electricity consumption increased but both insignificantly. However, the factors contributing to electricity saving behaviour and to actual electricity consumption were revealed to be different. Electricity saving behaviour was mostly determined by concerns about climate change and the war in Ukraine together with attitudes towards the increased energy expenses. As to actual electricity consumption, only concern about the military conflict and sceptical attitudes towards the energy crisis significantly but negatively influenced the levels of electricity consumption. Thus, this paper reveals that the war in Ukraine motivated people to perform electricity saving behaviour only due to the increased price, but the actual electricity consumption was not affected.

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  • Eruptive xanthomatosis, characterised by yellowish skin papules, is often associated with hypertriglyceridemia and can signal underlying systemic conditions such as uncontrolled diabetes. Here, we present the case of a 47-year-old woman with eruptive xanthomas and severe hypertriglyceridemia. Taking into consideration the multiple comorbidities, including type 2 diabetes, obesity, and a history of acute pancreatitis, the patient was treated with six courses of plasmapheresis, leading to complete resolution of the lesions and normal triglyceride (TG) levels.

      1
  • journal-article
    Tiškevičiūtė, Ugnė
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    Errichetti, Enzo
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    Lestani, Veronica
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    Stinco, Giuseppe
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    Plozner, Noemi
    Dermatology Practical & Conceptual, 2025-01-29, vol. 15, no. 1, p. 1-2
      1
  • Hypercholesterolemia, characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C), along with inflammation, is a well-known risk factor for developing atherosclerosis and coronary artery disease (CAD). Many patients with hypercholesterolemia may carry inherited genetic variants that are not part of the commonly recognized mutations in the LDLR, APOB, LDLRAP1, and PCSK9 genes. These genetic variants may have cumulative effects that contribute to increased LDL-C levels and CAD development. The polygenic risk score (PRS) may provide an essential tool for evaluating an individual’s genetic predisposition to these conditions. This pilot study aimed to investigate the impact of the PRS calculated from specific single nucleotide polymorphisms (SNPs) associated with LDL cholesterol (LDL-C)—namely, CELSR2 rs629301, APOB rs1367117, ABCG8 rs6544713, LDLR rs6511720, APOE rs429358, and rs7412—on LDL-C levels in both healthy individuals with elevated LDL-C levels (>2.6 mmol/L) and those diagnosed with ST-segment elevation myocardial infarction (STEMI). A total of 61 healthy individuals with high LDL-C levels (>2.6 mmol/L) and 93 STEMI patients were selected for the study. The High-Resolution Melting Polymerase Chain Reaction (HRM PCR) method was adopted and sequencing techniques were employed to identify the specific single nucleotide polymorphisms (SNPs) of interest. The patient group exhibited a PRS of 0.824 (with a range of −0.62 to 1.174) compared to 0.674 (range: −0.176 to 0.974) in healthy individuals, indicating a higher genetic predisposition to elevated LDL-C levels (p = 0.001) in patients. Interestingly, patients had lower LDL-C concentrations than healthy individuals. Additionally, a more significant number of patients were past smokers and statin users. The PRS calculations revealed that patients with a higher PRS had increased odds of experiencing an MI, with an odds ratio of 12.044 (95% confidence interval: 1.551–93.517, p = 0.017). Similarly, smokers showed even higher odds, with an odds ratio of 24.962 (95% CI: 7.171–86.890, p < 0.001). Among healthy individuals, those with a higher PRS had increased odds of having an LDL-C concentration greater than 4.9 mmol/L (odds ratio: 20.391, 95% CI: 1.116–358.486, p = 0.039). However, no significant association was found between the PRS and LDL-C levels in the patient group during hospitalization (p = 0.782). This pilot study shows that PRS can be employed to evaluate the risk of MI and to estimate concentrations greater than 4.9 mmol/L LDL-C in healthy individuals.

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