Rates of MTHFR and COMT Genes Polymorphisms in Patients with Depression
Suresh, Mary Fenita |
Recenzentas / Reviewer |
TITULAS: MTHFR ir COMT genų polimorfizmo rodikliai tarp depresija sergančių pacientų TIKSLAS: Įvertinti MTHFR ir COMT genų polimorfizmo paplitimą tarp depresija sergančių pacientų. TIKSLAI: 1. Įvertinti MTHFR genų polimorfizmo dažnį tarp depresija sergančių pacientų 2. Įvertinti COMT geno polimorfizmo dažnį tarp depresija sergančių pacientų 3. Palyginti MTHFR ir COMT genų dažnį tarp lyčių Išvada: Nors 57 proc. tyrimų nustatyta, kad MTHFR polimorfizmo dažnis buvo padidėjęs palyginti su kontroline grupe, kurioje nėra MDD, procentinis skirtumas daugiausia svyravo tarp sergančiųjų MDD ir kontrolinės grupės, kurioje nėra MDD. 0-3,5 %. Tarp tyrimų, kurie viršijo šį intervalą, buvo du tyrimai, atlikti Azijoje populiacijoje, iš kurių viename nustatytas net 27,7 % procentinis skirtumas, lyginant C677T MTHFR polimorfizmą tarp sergančiųjų MDD ir kontrolinės grupės asmenų. Panašiai ir tyrimas, atliktas kaukaziečių populiacijoje. Populiacijoje nustatytas 20,77 % skirtumas tarp A1298C MTHFR polimorfizmo ir A1298C MTHFR polimorfizmo tarp MDD atvejų ir kontrolinės grupės. Panašius rezultatus galima daryti ir su COMT polimorfizmu tarp abiejų kintamaisiais, nors padidėjęs sergančiųjų MDD grupėje, jis yra labai nedidelis, rodantis ribotą įtaką. Kalbant apie lyties įtaką MTHFR ir COMT polimorfizmui, nėra išvadų, kurias būtų galima padaryti. Padaryti, nes lyčių skirtumai priklauso nuo patologijos ir yra per maži, kad būtų reikšmingi, kartais polimorfizmo lygis padidėja vyrams, o kartais - moterims. Reikia atlikti tolesnius tyrimus siekiant nustatyti tvirtus šių kintamųjų ryšius.
AUTHOR: MaryFenita Suresh TITLE: Rates of MTHFR and COMT genes polymorphisms in patients with depression AIM: To evaluate rates of MTHFR and COMT gene polymorphism in patients with depression OBJECTIVES:
- To evaluate the frequency of MTHFR gene polymorphism in patients with depression
- To evaluate the frequency of COMT gene polymorphism in patients with depression
- To compare MTHFR and COMT gene rates between genders METHODOLOGY: Search engines such as Pubmed, Google Scholars, and ScienceDirect helped find studies which contained the keywords: MTHFR, polymorphism, COMT, depression, and gender. The studies were then chosen if they had the keywords mentioned above, if the researcher did some sort of scale which measured depression and used a gene polymorphism detection technique. For the results which needed information about gender, I had to ensure that the statistics describing COMT/MTHFR polymorphism was stated for males and females therefore it could be compared. RESULTS: 57% of the studies that investigated MTHFR polymorphism in those with MDD vs controls who did not suffer from MDD found that the rate of polymorphism was increased in those with MDD. 67% of the studies that investigated COMT polymorphism in those with MDD vs controls found that the rate of polymorphism was increased in those with MDD. Females were affected more than males with MTHFR polymorphism in 29% of the studies and were more affected than males in 40% of cases when comparing COMT gene polymorphism. The rate difference between male and females when comparing COMT or MTHFR polymorphism was very low ranging between 0-3%, with only one study exceeding these findings with a percentage rate difference of 12.5% when comparing cases of leukaemia. CONCLUSION: Even though 57% of studies found that MTHFR polymorphism rate was increased in those with MDD in comparison to controls without MDD, the rate difference in percentage majorly ranged between 0-3.5%. The studies that exceeded this range included two studies conducted in an Asian population, one finding a rate percentage difference as high as 27.7% when comparing C677T MTHFR polymorphism in those with MDD vs controls. Similarly, a study that was conducted in a Caucasian population found a rate difference of 20.77% when studying the A1298C MTHFR polymorphism between MDD cases and controls. Similar results can be concluded with COMT polymorphism between both variables, even though increased in those with MDD, it is very modest, showing limited influence. In terms of gender’s influence of MTHFR and COMT polymorphism, there are no conclusions that can be drawn, as the gender differences depend on the pathology and are too close in variance to be significant, sometimes males had increased levels of polymorphism and sometimes females. Further research has to be conducted to find solid relations between these variables