Milk Thistle (Silybum Marianum (L.)),Common Dandelion (Taraxacum Officinale (L.)), Globe Artichoke (Cynara Scolymus (L.)) Powder Capsules Technology

Abstract

Project aim: to create Milk thistle (Silybum marianum (L.)), Common dandelion (Taraxacum officinale (L.)), Globe artichoke (Cynara scolymus (L.)) powder capsules and evaluate quality of them by choosing the right technology Tasks of study: to collect scientific publications and analyze articles on the raw material of Milk thistle (Silybum marianum (L.)), Common dandelion (Taraxacum officinale (L.)), Globe artichoke (Cynara scolymus (L.)) it‘s active substances and their effect. Properly select the composition and production technology for the powder mixture of these plant raw materials. To make capsules suitable for consumption. Carry out quality assessments of the producted capsules. Research object: Milk thistle (Silybum marianum (L.)) fruits, Common dandelion (Taraxacum officinale (L.)) roots, Globe artichoke (Cynara scolymus (L.)) leaves powder and the capsules made of their mixture. Methods: the technological properties of the Milk thistle, Common dandelion and Globe artichoke powder were evaluated by doing: sieve test, flow and angle of repose tests, tap dansity, compressibility index and Hausner ratio tests. Formulated suitable filler for the capsules. Encapsulation was done. Stability assessment, mass uniformity and disintegration time tests were performed for the manufactured capsules. Antimicrobal activity study of Milk thistle, Common dandelion and Artichoke‘s powder and their mixture using agar diffusion methode. Results: ground powders of Milk thistle fruit, Common dandelion root and Globe artichoke leaves and their mixtures had a sticky, too light and fine texture. For encapsulation, it was chosen to use pure powder of these plant raw materials in ratio of 1:1:1. The manufactured capsules met the requirements of mass uniformity and disintegration time tests. During the stability test, capsules were stored for 3 months at room temperature and in the refrigerator and met the established requirements. It was found that the mixture of produced powders showed antimicrobial activity against P.vulgaris bacteria species. Conclusion: after carrying out a technological assessment of the mixture of Milk thistle fruits, Common dandelion roots, Globe artichoke leaves powder and analysis of the quality of the capsules, it was found that they meet the requirements set by European Pharmacopoeia and are suitable for further research.