Serum C-reactive protein concentration in chronic urticaria patients.

The aim of the theses: To investigate serum C- reactive protein level in patients with chronic spontaneous urticaria. Objectives of the study: 1.To identify serum C- reactive protein levels in patients with chronic spontaneous urticaria. 2. To evaluate serum C-reactive protein levels according to the activity of chronic spontaneous urticaria. 3. To determine serum C- reactive protein levels in chronic spontaneous urticaria patients with positive autologous serum skin test. 4. To evaluate peripheral blood autoimmunity markers (anti-TPO and ANA) according to the activity of chronic spontaneous urticaria. Methodology: This study is a retrospective analysis of medical records and laboratory test results of 48 patients with chronic spontaneous urticaria. All of them were consulted during 2015-2016 in department of Immunology and Allergology at the hospital of Lithuanian University of Health Sciences Kaunas clinics. According composite measure of itch severity and number of hives over 7 days (urticaria activity score 7), patients with chronic spontaneous urticaria were divided into 3 groups: mild urticaria (1-15), moderate urticaria (16-27) and severe urticaria (28-42); according autologous serum skin test results patients with chronic spontaneous urticaria were divided into 2 groups: autologous serum skin test positive and negative group. Serum CRP levels were measured using high-sensitivity CRP reagent kits (Dade Behring, USA) with a protein analyzer BNTM100 N. Statistical analysis was performed using SPSS statistics for Windows v. 20.0. Results: The patients with severe chronic spontaneous urticaria had higher C- reactive protein levels compared with the patients suffering from mild and moderate chronic spontaneous urticaria (3.6 (1.8) vs 0.6 (0.5) and 0.7 (0.8) mg/L, P< 0.05). 9 patients (30%) with positive autologous serum skin test had higher urticaria activity score 7, compared with 21 patients (70%) with negative autologous serum skin test (38 (7) vs 20 (10), P< 0.05). There were no significant differences in the C-reactive protein levels in chronic spontaneous urticaria patients with positive and negative autologous serum skin test. Conclusions: 1. chronic inflammation are common in patients with chronic spontaneous urticaria, the prevalence of patients with increased serum CRP levels is 21%. 2. Serum C- reactive protein levels were significantly higher in patients with severe chronic spontaneous urticaria 3. There were no differences in C- reactive protein levels in chronic spontaneous urticaria patients with positive and negative autologous serum skin test. 4. No difference was found between immunity markers (anti-TPO and ANA) to disease activity.

Tyrimo tikslas: įvertinti C reaktyviojo baltymo koncentraciją sergant lėtine spontanine dilgėline. Uždaviniai: 1. Įvertinti C reaktyviojo baltymo koncentraciją sergančiųjų lėtine spontanine dilgėline kraujo serume. 2. Palyginti C reaktyviojo baltymo koncentraciją kraujo serume esant skirtingam lėtinės spontaninės dilgėlinės aktyvumui. 3. Nustatyti C reaktyviojo baltymo koncentraciją sergantiems lėtine spontanine dilgėline, kuriems nustatytas teigiamas autologinio serumo testas. 4. palyginti autoimuninių žymenų ( AntiTPO , ANA) periferiniame kraujyje dažnį esant skirtingam lėtinės spontaninės dilgėlinės aktyvumui. Išvados: 1. C reaktyvaus baltymo koncentracijos padidėjimas kraujo serume nustaytas daugeliui tirtųjų asmenų, sergančių lėtine spontanine dilgėline. 2. Didesnė C reaktyvaus baltymo koncentracija kraujo serume nustatyta sergant sunkios eigos lėtine spontanine dilgėline 3. C reaktyvaus baltymo koncentracijos skirtumų tarp sergančiųjų lėtine spontanine dilgėline esant teigiamam ar neigiamam autologinio serumo testui, nenustatyta. 4. Autoimuninių žymenų nustatytmo kraujyje dažnis nepriklauso nuo lėtinės spontaninės dilgėlinės aktyvumo.