B grupės streptokokas kolonizacija nėščioms moterims ir poveikis motinos bei naujagimių rezultatams

Hollender, Yair

Use this url to cite ETD: https://hdl.handle.net/20.500.12512/118536

Group B Streptococcus Colonization in Pregnant Women and Effect on Maternal and Neonatal Outcomes

Type of publication

type::text::thesis::master thesis

Title

Group B Streptococcus Colonization in Pregnant Women and Effect on Maternal and Neonatal Outcomes

Other Title

B grupės streptokokas kolonizacija nėščioms moterims ir poveikis motinos bei naujagimių rezultatams

Author

Hollender, Yair

Advisor

Malakauskienė, Laura

Other(s)

Tarasevičienė, Viktorija	Recenzentas / Reviewer
Kliučinskas, Mindaugas	Komisijos pirmininkas / Committee Chairman
Jarienė, Kristina	Komisijos narys / Committee Member
Gaurilčikas, Adrius	Komisijos narys / Committee Member

Extent

27 p.

Thesis Defence Date

2023-06-13

Keywords (lt)

Group B Streptococcus...

GBS

GBS colonization

GBS prophylaxis

Maternal and neonatal...

B grupės streptokokas...

BGS

BGS kolonizacija

BGS profilaktika

Motinos ir naujagimio...

Abstract (lt)

Author name: Yair Hollender Research title: Group B Streptococcus Colonization in Pregnant Women and Effect on Maternal and neonatal outcomes. Aim: To analyze GBS colonization prevalence among pregnant women and how GBS effect neonates and pregnant women. Objectives:

To evaluate GBS colonization prevalence among pregnant women.
To determine the relationship between GBS colonization and postpartum and neonatal complications.
To determine the relationship between GBS colonization and maternal and neonatal long-term complications.
To analyses the impact of GBS colonization on the course of pregnancy and delivery.
To investigate the current treatment of GBS and possibilities of GBS prevention. Material and methods: The research and data collection in this literature review was performed by reviewing the most relevant literature regarding Group B Streptococcus colonization effects on pregnant women and neonates according to the aims and objectives of the study. The main resource for the literature were PubMed and Google Scholar which yielded 33 relevant articles when applying the selected key-words and according to the inclusion and exclusion criteria. Conclusions: 1. The overall prevalence of GBS colonization among the pregnant population is approximately 21%, Serotypes Ia, Ib, II, III, and V, accounting for about 98% of the colonizing serotypes globally. Risk factors for GBS colonization includes increased maternal age, higher parity women (≥2). 2. GBS related complications during pregnancy are stillbirths, preterm birth, and intrauterine infections. 3. Neonatal GBS related diseases includes sepsis, pneumonia, meningitis, and neonatal encephalopathy. 4. Most common maternal GBS related diseases are urinary tract infections and post-partum endometritis. 5. The current preventative measures include screening for GBS colonization, identifying risk population and intrapartum antibiotic prophylaxis. Currently, anti-GBS vaccines are in the process of development. Practical recommendations: All pregnant women should be screened for GBS colonization between 36 0/7 and 37 6/7 weeks of gestation. Intrapartum antibiotic prophylaxis is indicated for women with a positive GBS, as well as women who consider at risk. The dose of Penicillin should be 5 million units IV load then 2.5-3 million units IV every 4 hours until delivery. Although IAP has reduced the rate of GBS the global burden is still significant. Therefore, the development of future preventive measures such as GBS vaccine is extremely important and should be encouraged and supported.

Abstract (en)

Autorius: Yair Hollender Vadovas: Assoc. Prof. Laura Malakauskienė Tyrimo pavadinimas: B grupės streptokokas kolonizacija nėščioms moterims ir poveikis motinos bei naujagimių rezultatams. Tikslas: Išanalizuoti BGS kolonizacijos paplitimą tarp nėščių moterų ir kaip BGS veikia naujagimius ir nėščias moteris. Tikslai:

Įvertinti BGS kolonizacijos paplitimą tarp nėščių moterų.
Nustatyti ryšį tarp BGS kolonizacijos ir pogimdyminių bei naujagimių komplikacijų.
Nustatyti ryšį tarp BGS kolonizacijos ir motinos bei naujagimio ilgalaikių komplikacijų.
Išanalizuoti BGS kolonizacijos įtaką nėštumo eigai ir gimdymui.
Ištirti dabartinį BGS gydymą ir BGS prevencijos galimybes.