Endometrium proliferation and Ki67: a closer look at a malignancy potential of asympyomatic postmenopausal endometrial polyps
| Author | Affiliation |
|---|---|
Nickkho-Amiry, Mahshid | University of Manchester and St Marys Hospital, Manchester, UK |
Holland, Cathrine | University of Manchester and St Marys Hospital, Manchester, UK |
Seif, Mourad W. | University of Manchester and St Marys Hospital, Manchester, UK |
| Date |
|---|
2018-04-13 |
ISBN 978-9955-15-530-0. Language of abstracts was not corrected.
Introduction. The majority of postmenopausal polyps are benign but a small proportion, i.e. 4.47% among symptomatic postmenopausal women in comparison to 1,51% of asyptomatic women of polyps are malignant. There is no wide consensus in the literature on the clinical significance and management of asymptomatic polyps. It appears that the risk of endometrial carcinoma in postmenopausal women with asymptomatic endometrial polyps is low, although a larger series is required to confirm this finding. The aim. To investigate the proliferation in endometrial polyps as an indicator of their oncogenic potential in postmenopausal women with no history of bleeding. Material and methods. Immunohistochemical studies of Ki67, using monoclonal antibodies MIB-1, were performed. Cases included 52 benign postmenopausal polyps, 19 endometriois carcinoma with coexisting benign polyps. 12 polyps with foci of carcinoma and 4 cases of polyps which later developed carcinoma. [...].