Use this url to cite publication: https://hdl.handle.net/20.500.12512/20775
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Age-related responses of brain mitochondria to ischaemic stroke / Arandarcikaite Odeta, Borutaite Vilmante
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Title
Age-related responses of brain mitochondria to ischaemic stroke / Arandarcikaite Odeta, Borutaite Vilmante
Publisher (trusted)
World Mitochondria Society
Date Issued
2018-10-23
Extent
p. 66-66.
Is part of
Journal of World Mitochondria Society - Archives : 9th world congress on targeting mitochondria : October 24-25, 2018, Berlin, Germany : abstracts book / World Mitochondria Society. [S.l.] : World Mitochondria Society, 2018, vol. 4, iss. 1.
Version
Originalus / Original
Series/Report no.
Abstracts for poster presentation by alphabetic order.
Description
Supported by Research council of Lithuania, Global grant Nr. 09.3.3-LMT-K-712-01-0131.
ISBN 978-2-35609-009-6.
Bibliogr.: p. 66
Field of Science
Keywords
Abstract
Introduction: The increased risk of ischaemic stroke is related to aging. Previously we reported that ischemia inhibits mitochondrial respiration, but ischemia- induced MPTP does not cause the release of cytochrome c. The inhibition of MPTP formation just partly protected against necrosis. Methods: In this study, we evaluated 90 min. ischemia-effect on mitochondrial respiration and, calcium retention capacity (CRC) in the 7 days, 2-3, 10 and 24 month rats cerebellum characterised as neurons rich region and cerebral cortex as astrocytes rich region. Results: We found that ischaemia caused persistent inhibition of respiration of mitochondria isolated from cortex at all ages of animals. However, CRC of cortical mitochondria was decreased after ischaemia only 2-24 months rats, whereas neonatal mitochondrial CRC has no statistically significant difference from control. Ischaemia induced inhibition of cerebellar mitochondrial respiration at the age of 7 days, 2-3 and 24 months, whereas CRC after ischaemia decreased only in mitochondria from cerebellum of 10-24 months rats. Conclusion: Altogether data suggest that ischaemia induced injuries to mitochondria are related with age of the animal and region of the brain. . [...].
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)990000973400107106
Coverage Spatial
Vokietija / Germany (DE)
Language
Anglų / English (en)