Left ventricular fibrillar collagenous matrix remodelling in chronic ischemia
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2011-08-27 |
Objective: The aim of the study was to evaluate peculiarities of human myocardial interstitial collagen matrix remodelling in the left ventricular myocardium due to chronic ischemia. Method: Hearts of suddenly deceased males who died suddenly out-of-hospital (within 6 h of the onset of the terminal event) due to the first acute (n=51) and repeated (n=35) event of ischemic heart disease (IHD) were studied. The control group consisted of males (n=26) of similar age who succumbed to external causes. Collagen was stained with picro-sirius red, computerised image analysis system was applied for histomorphometry. Results: Interstitial collagen percentage volume, perimeter and the number of separate foci of fibres per field of left ventricular myocardium in the pre-infarction IHD group was greater than in the controls (by 31%, 26% and 19%, respectively, p<0.05). The induced collagen matrix remodelling process progresses during the post-infarction phase: collagen percentage volume of left ventricular myocardium was higher by 40%, matrix perimeter by 39%, and number of fibres per field by 32% in the post-infarction IHD group as compared with the same indices of pre-infarction IHD group (p<0.05). Conclusion: Remodelling of left ventricular myocardium interstitial collagen network is induced due to chronic myocardial ischemia (before the first myocardial infarction) and progresses after the myocardial infarction.