Frequency of HLA DR-DQ haplotypes in Lithuanian children with type 1 diabetes and controls
| Author(s) | ||
|---|---|---|
Linköping University Hospital, Sweden | ||
Sanjeevi, Carani B | Karolinska Institute, Department of Molecular Medicine, Stockholm | |
Ludvigsson, Johnny | Linköping University Hospital, Department of Pesiatrics, Linköping |
| Date Issued |
|---|
2008-09-20 |
ISBN 978-3-8055-8620-7.
Susceptibility and resistance to type 1 diabetes mellitus (DM) are strongly associated with HLA DR and DQ alleles. The aim of this study was to estimate the frequency of HLA DR-DQ haplotypes related and protective to type 1 diabetes in Lithuanian children with type 1 diabetes mellitus and controls. The study was designed as a case-control study. 124 (55 male and 69 female, mean age 9.2±3.9 years) diabetic children were tested for HLA and compared with 78 controls (43 males and 35 females, mean age 11.0±3.4 years). HLA DRB1, DQA1 and DQB1 typing was done by polymerase chain reaction and hybridization with allele specific oligonucleotide probes. Risk haplotypes DR3-DQA10501-DQB10201 and/or DR4-DQA10301-DQB10302 were present in 79% (98/124) diabetic children compared with 15.4% (12/78) controls (p<0.001). Table 1 shows odds ratios (OR) of risk DR and DQ phenotypes and genotypes for type 1 DM and control children. [...].