High concordance rates of premalignant gastric lessions assesed by OLGA and OLGIM in monozygotic and dyzigotic twins
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2019-10-19 |
Introduction: The development and progression of chronic H.pylori gastritis toward pre-neoplastic gastric lesions is a multifactorial process, which depends on interactions between environmental factors, H.pylori infection, gastric microbiota and host genetic factors. To date, there are no studies that would evaluate the role of shared genetic influences on susceptibility and phenotype of chronic H.pylori gastritis and premalignant gastric alterations in twins. Aims & Methods: To compare histological alterations of gastric mucosa according to Sydney classification, OLGA and OLGIM staging systems in monozygotic and dizygotic twins. This prospective study included 58 individuals with 13 pairs of monozygotic and 16 pairs (11 same- sex pairs and 5 mixed- sex pairs) of dizygotic twins aged >18 years. Endoscopy for both twins was performed simultaneously on the same day. At endoscopy 5 biopsy specimens were collected: 2 from the greater and lesser curvatures of antrum, 1 from incisura angularis, 2 from the anterior and posterior walls of the corpus. H. pylori gastritis was assessed by histology and graded by OLGA and OLGIM staging systems. Results: Mean age of monozygotic and dizygotic twins was 41.23 y and 38.43 y, respectively. Total prevalence of H.pylori was 53.4%. Among monozygotic twins, six pairs were both positive, three pairs were both negative and four pairs were discordant for the presence of H.pylori. Among dizygotic twins, four pairs were both positive, five pairs were both negative and seven pairs were discordant for presence of H.pylori. Concordance rate for chronic H.pylori gastritis in monozygotic twins was 69.2 % (9/13 pairs) and in dizygotic twins 62.5% (10/16 pairs), p>0.05. Concordance for antrum athrophy in monozygotic twins was 76.9 % and 75 % in dizygotic twins (p> 0.05). Concordance for corpus athrophy in monozygotic twins was 92.3% and in dizygotic twins 87.5% (p>0.05). Concordance for antr[...].