Characterization of cervical morphological changes patterns in reproductive and postmenopausal women
| Other(s) | ||
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Tyrimo grupės vadovas / Research group head | ||
Tyrimo grupės vadovas / Research group head |
| Date |
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2021-03-22 |
Basic & preclinical science (morphology, pathology, genetics)
ISBN 978-9934-8927-5-2.
Authors are responsible for their Abstracts.
Objectives. In postmenopausal women the level of oestrogen decreases as progesterone increases, causing development of structural changes of genitalia. Thus, the aim of this research is to evaluate the morphology of cervical changes in reproductive and postmenopausal women. Materials and Methods. Research was approved by the Lithuanian University of Health Sciences (LUHS) Bioethics centre. Patients who underwent hysterectomy in Obstetrics and Gynaecology clinic at LUHS Hospital Kaunas Clinics and pathology testing of excised specimens in 2018 were included. Prepared haematoxylin–eosin stained histological slides were examined by light microscopy for cervical structural changes. Statistical significance was considered as p<0.05. Results. Overall, 520 total hysterectomies were performed in 2018 at LUHS Hospital Kaunas Clinics, the average age of subjects – 59.75±12.477 years old, and 29.5% (n=154) of them were of reproductive age. Cervicitis was detected in 59.6% (n=310) of subjects. Rates of cervicitis, cervical metaplasia, hyperplasia and atrophy were similar in reproductive and postmenopausal age groups (p>0.05). Cervical metaplasia was identified in 6.5% (n=10) of reproductive age subjects, 3.9% (n=6) had hyperplasia, while atrophy was detected twice (1.3%). In postmenopausal group metaplasia, hyperplasia and atrophy, were identified in 3.6% (n=13), 5.7% (n=21) and 3.6% (n=13) patients respectfully. Nebothian cysts were more likely to be identified in postmenopausal age (79.7%, n=188; p<0,001). Structural neoplastic changes were detected in 11.5% (n=60) of patients. Notably, atypical changes of cells in cervical epithelium were more common among patients of reproductive age (p=0,009). It was 3.008 times more likely to find cell atypia in reproductive age subjects (95% CI 1.271-7.120). Conclusions. Cervicitis, metaplasia and hyperplasia are detected in similar rates at reproductive and postmenopausal age, [...].