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Antimicrobial properties of thiophene derivatives
Šarlauskas, Jonas | ||
Vilniaus universitetas. Biotechnologijos institutas |
Date Issued |
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2014-06-19 |
Bibliogr.: p. 23
Irrational use of antibiotics causes antimicrobial resistance that increases the need to search for the new antimicrobial agents. It was determined that various thiophene amide derivatives showed similar activity as chloramphenicol against S. aureus (1). Dinitrothiophene derivatives were very active against Mycobacterium pathogenic strains (2). Some other thiophene-bearing compounds were active against fungi, including C. albicans (3). The aim of this study was to test the antimicrobial activity of new thiophene derivatives. Antimicrobial (antibacterial and antifungal) activity of these compounds was pre-screened in vitro using ten microbial cultures. The results of experiments in vitro showed that activity against various microorganisms was different. Five compounds showed activity against B. subtilis, B. cereus and S. epidermidis (MICs varied in the range of 5-25 μg/ml). The most active compounds were the ones with electron acceptor substitutes (nitro group, chlorine) in thiophene and benzene rings. The obtained preliminary results ofter a great potential for further exploration of thiophene derivatives.