Prevalence of metabolic syndrome using who, ATP III, and IDF definitions and risk of ischemic heart disease among Kaunas (Lithuania) adult population

Abstract

Aim: To compare the prevalence of metabolic syndrome (MS) using three different definitions, and their ability to identify risk of ischemic heart disease in Kaunas (Lithuania) adult population. Methods: The epidemiological examination was carried out in Kaunas according to the MONICA study protocol. Analysis was performed for 1336 persons aged 35–64 years (603 men and 733 women). MS was defined by World Health Organization (WHO), Adult Treatment Panel III (ATPIII), and International Diabetes Federation definitions (IDF). Ischemic heart disease (IHD) was determined according to documented history myocardial infarction, angina pectoris or ischemic changes of electrocardiogram. Results: MS was identified for 11.3% of men and for 9.4% of women using WHO definition, for 19.4% of men and for 26.3% of women using ATPIII definition, and for 30.0% of men and for 37.7% of women using IDF definition. In men and women groups the prevalence of the MS (irrespective of definition) significantly increased with age (p<0.05). Adjusted for age, men with MS according to the IDF definition (OR=2.30; p=0.001) and ATPIII definition (OR=1.97; p=0.01) and women with MS according to the IDF definition (OR=1.50; p=0.039) had significantly higher risk for IHD compared with those without MS by the same definitions. MS according to WHO definition was not associated with a significant IHD risk in men and women. Conclusion: In Kaunas adult population the highest prevalence of MS was determined according to the IDF definition. Using the IDF and the ATPIII definitions for MS provides more opportunities to identify subjects with IHD.