PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese

Sjakste, Tatjana; Paramonova, Natalia; Wu, Lawrence Shi-Shin; Žemeckienė, Živilė; Šitkauskienė, Brigita; Sakalauskas, Raimundas; Wang, Jiu-Yao; Sjakste, Nikolajs

doi:10.1016/j.mgene.2014.03.002

Use this url to cite publication: https://hdl.handle.net/20.500.12512/91869

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese

Type of publication

Straipsnis Scopus duomenų bazėje / Article in Scopus database (S1b)

Author(s)

Author	Affiliation
Sjakste, Tatjana

Title

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese

Tatjana Sjakste, Natalia Paramonova, Lawrence Shi-Shin Wu, Zivile Zemeckiene, Brigita Sitkauskiene, Raimundas Sakalauskas, Jiu-Yao Wang, Nikolajs Sjakste

Publisher (trusted)

Elsevier

Is Referenced by

Scopus

EmBiology

Date Issued

Date	Volume	Start Page	End Page
2014-04-17	2	283	298

Is part of

Meta gene

Version

Originalus / Original

Series/Report no.

Original research article

Field of Science

Medicina / Medicine (...

Keywords (en)

Proteasome endopeptid...

Adenosine triphosphat...

Genetic variation

Polymorphism, single ...

Latvia

Lithuania

Taiwan

Abstract (en)

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity was investigated in 1438 unrelated subjects from Latvia, Lithuania and Taiwan. In general, polymorphism of each individual locus showed tendencies similar to determined previously in HapMap populations.Main differences concern Taiwanese and include presence of rs2277460 rare allele A not found before in Asians and absence of rs2295827 rare alleles homozygotes TT observed in all other human populations. Observed patterns of SNPs and haplotype diversity were compatible with expectation of neutral model of evolution. Linkage disequilibrium between the rs2295826 and rs2295827 was detected to be complete in Latvians and Lithuanians (DV= 1;r2 = 1) and slightly disrupted in Taiwanese (DV= 0.978; r2 = 0.901).