Associations between migraine, celiac disease, non-celiac gluten sensitivity and activity of diamine oxidase
| Author | Affiliation | |
|---|---|---|
Griauzdaitė, Karolina | ||
| Date |
|---|
2020-11-19 |
Neurosciences
Karolina Griauzdaitė Lithuanian University of Health Sciences, Kaunas, Lithuania
The Conference is organized by the Student’s Scientific Society of Lithuanian University of Health Sciences The content of the abstract book is redacted. The Student’s Scientific Society of Lithuanian University of Health Sciences did not have control over the abstracts. The authors remain responsible for the content of their respective abstracts. All abstracts presented in the conference were reviewed.
Bibliogr.: p. 73-74
Introduction Recent reports reveal a close relationship between migraine and gastrointestinal disorders (GI), such as celiac disease (CD) and non-celiac gluten sensitivity (NCGS). CD is a genetic autoimmune disorder, which affects the mucosa of the small intestine. Gluten, found in various grains, not only plays a major role in the pathophysiology of CD and NCGS, but also aggravates migraine attacks. Another common food component, which can induce migraine headaches, is histamine. Diamine oxidase (DAO) is an enzyme, which degrades histamine. Reduced activity of DAO means reduced histamine degradation, which can cause histamine build-up and lead to various symptoms, including headaches and migraine. Aim To evaluate the relationship between decreased DAO activity and the occurrence of celiac disease and NCGS in patients with severe migraine. To evaluate the possible change in the impact of migraine on patient’s daily activities after proper dietary recommendations are given. Methods A random sample of 44 patients (5 male, 39 female, aged 18+, mean age 41,31±95% CI 37,93-44,70) with severe migraine, treated in Hospital of Lithuanian University of Health Sciences Kauno klinikos from December 2015 to December 2016 were enrolled in efforts to evaluate the co-presence of decreased serum DAO activity and celiac disease/NCGS in patients. Patients were randomly divided into 2 groups: decreased DAO activity (group 1; n=26) and normal DAO activity (group 2; n=18). All patients were screened for celiac disease. The diagnosis of NCGS was made after exclusion of CD, food allergies and other GI disorders in the presence of gluten sensitivity symptoms. Furthermore, dietary recommendations were given... [...].