Impaired LV mechanics in end stage renal disease patients with preserved LV systolic function undergoing hemodialysis
| Date |
|---|
2018-12-05 |
Background. Cardiovascular diseases are the most common and life threatening comorbidities in patients with end stage renal disease (ESRD). The parameters of conventional echocardiography are not enough sensitive for detecting early cardiac dysfunction in chronic kidney disease patients. Purpose. The aim of our study was to evaluate changes of LV systolic function and deformation obtained by speckle-tracking echocardiography (STE) in patients with the ESRD undergoing hemodialysis (HD). Methods. The conventional echcardiography was performed to 70 patients with preserved LV EF (>50%) who were divided into two groups: HD group – patients with ESRD undergoing HD (n=38) vs. controls – patients with normal kidney function (GFR>90mL/min/1.73m2) (n=32). Longitudinal, radial and circumferential LV strains were analysed using 2D STE. Statistical analyses were performed using the SPSS 20.0 software. Differences of characteristics between groups were assessed using the unpaired Student t test, Mann-Whitney, and Chi-square test. The value of p<0.05 was considered as statistically significant. Results. There were no significant differences of clinical characteristics and comorbidities between groups. LV S‘ of septal, lateral, inferior and anterior walls were significantly lower in HD group (8.27±1.95 vs 9.71±1.77, p=0.004, 9.83±3.24 vs 11.19±2.75, p=0.020, 9.11±2.22 vs 10.51±1.93, p=0.012, 9.11±2.22 vs 10.92±1.93, p<0.001, respectively). LV longitudinal strain, circumferential strain at mitral valve and papillary muscles levels were significantly lower in HD patients compared to controls. There were no differences in LV radial strain parameters between the groups at all levels of short axis (Table1). Conclusion. ESRD is associated with reduced LV longitudinal and circumferential strains measured by STE in patients with preserved LVEF. LV myocardial deformation parameters obtained by STE Characteristic Control[...].