Evaluation of the Radiosensitizing Potency of Luteolin for MCF-7 Breast Cancer Cells

Abstract

Background and Objectives Radiotherapy is an important treatment modality in modern cancer therapy besides surgery and systemic therapy. However, radioresistance of breast cancer cells remains the major limiting factor of this treatment option. Therefore, there is a need for research related to compounds that can improve the radiotherapy effect. One of these is luteolin (LUT). Luteolin, a flavonoid that is found in many fruits, vegetables, and herbs, exhibits numerous biological activities, including anti-inflammatory, antidiabetic, and anticancer properties. Through a variety of experimental cancer models, luteolin has been extensively researched in many cancer types and has been related to its ability to inhibit tumor growth by targeting cellular processes such as apoptosis, angiogenesis, migration, and cell cycle progression. However, a knowledge gap remains regarding the studies on luteolin efficacy and its the mechanism of radiosensitization. Thus, the aim of this work was to analyze the potential radiosensitizing effect of luteolin on MCF7 breast cancer cells. [...].