Postoperative hypophosphatemia as a prognostic factor for postoperative pancreatic fistula: a systematic review

Abstract

Introduction Postoperative pancreatic fistula (POPF) is one of the most challenging complications after pancreatic resection, associated with prolonged hospital stay and high mortality [1, 2]. Early identification of pancreatic fistula is important for the treatment to be effective. Several prognostic factors have been identified, although it is not clear which one is the most significant [2]. Some studies show that postpancreatectomy hypophosphatemia may be associated with the development of POPF [3]. AimTo perform a systematic literature review on postoperative hypophosphatemia as a prognostic factor for postoperative pancreatic fistula. Methods The systematic literature review was performed according to preferred reporting items for systematic reviews (PRISMA) statements and was registered in the International prospective register of systematic reviews (PROSPERO). The PubMed, ScienceDirect and Web of Science databases were systematically searched up to 31st of January 2022 for studies analyzing postoperative hypophosphatemia as a prognostic factor for postoperative pancreatic fistula. Data including study characteristics, patient characteristics, operation type, definitions of postoperative hypophosphatemia and postoperative pancreatic fistula were extracted. Results Initially, 149 articles were retrieved. After screening and final assessment, 3 studies with 3022 patients were included in this review. Association between early postoperative hypophosphatemia and the postoperative pancreatic fistula was found in all included studies. […].