Nasal Chondromesenchymal Hamartoma in dogs

Abstract

1. Introduction. There are only few reports about nasal cavity masses resembling chondro-osseous respiratory epithelial adenomatoid hamartomas (COREAH) in dogs (1,3). We did not found any references about nasal chondromesenchymal hamartoma (NCMH) in dogs and other animals. NCMH in human is a very rare, benign tumor of the sinonasal tract (2). These unusual lesions are com-posed of a proliferation of mesenchymal and cartilaginous elements. Their pathogenesis is unknown, but they may be derived from embryologic rests (2,4). Histologically was seen well demarcated areas of immature and mature car-tilage (Fig. 1), aneurysmal bone cyst-like formations (Fig. 1 arrow), myx-oid stroma, spindle cells, collagen fibers (Fig. 2), focal osteoclast-like giant cells (Fig. 3, arrow). Both dogs recovered well after surgery, recurrence were not noted.Materials and methods. Two cases of chondromesenchymal hamartoma in dogs were diagnosed during routine histopathology of surgical specimens: 1 year female French bulldog, and 3 years mixed breed male. Dogs were investigated clinically, and by computed tomography imaging (CTI). The removed masses were fixed in 10% formalin. The HE stained slides were evaluated using the Olympus microscope supplied with a digital Olympus DP72 image camera with CellSensDimension software. [...].