Use this url to cite publication: https://hdl.handle.net/20.500.12512/238046
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Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control
Type of publication
Straipsnis Web of Science ir Scopus duomenų bazėje / Article in Web of Science and Scopus database (S1)
Author(s)
Radzevičiūtė-Valčiukė, Eivina | Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras |
Balevičiūtė, Austėja | Karolinska Institutet |
Želvys, Augustinas | Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras |
Zinkevičienė, Auksė | Valstybinis mokslinių tyrimų institutas Inovatyvios medicinos centras |
Title
Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control
Publisher (trusted)
Date Issued
2023-08-11
Is part of
Veterinary Sciences
Version
Originalus / Original
Description
Art. no. 519.
This article belongs to the Special Issue Nutraceuticals to Mitigate the Secret Killers in Animals
Volume
10
Issue
8
Start Page
1
End Page
20
Field of Science
OECD Classification
Abstract
Bovine colostrum (COL), the first milk secreted by lactating cows postpartum, is a rich source of bioactive compounds that exert a significant role in the survival, growth, and immune development of neonatal calves. This study investigated the immunomodulatory effects of COL on cytokine production in vitro using a Caco-2/THP-1 macrophage co-culture model stimulated with Phorbol 12-myristate 13-acetate (PMA). COL pretreatment significantly reduced IL-6 (241.3 pg/mL) production induced by PMA (p < 0.05), while increasing IL-10 production (45.3 pg/mL), in comparison to PMA control (441.1 and 12.5 pg/mL, respectively). Further investigations revealed that the IL-6 suppressive effect of colostrum was heat-sensitive and associated with components of higher molecular mass (100 kDa). Moreover, colostrum primarily influenced THP-1 macrophages rather than Caco-2 epithelial cells. The effects of colostrum on IL-6 production were associated with reduced NF-κB activation in THP-1 macrophages. In calf-FMT transplanted C57BL/6 murine model, colostrum decreased intestinal permeability, reduced immune cell infiltration and intestinal score, and suppressed IL-6 (142.0 pg/mL) production during S. typhimurium infection, in comparison to control animals (215.2 pg/mL). These results suggest the immunomodulatory activity of bovine colostrum and its potential applications in inflammatory disorders. Further studies are needed to elucidate the underlying mechanisms and validate the findings in bovine models.
Is Referenced by
Type of document
type::text::journal::journal article::research article
ISSN (of the container)
2306-7381
Other Identifier(s)
PMCID: PMC10458264
Coverage Spatial
Šveicarija / Switzerland (CH)
Language
Anglų / English (en)
Bibliographic Details
59
Funding(s)
Funding(s) | Grant No |
---|---|
Lietuvos sveikatos mokslų universiteto Mokslo fondas | 119-05 |
Date Reporting
2023
Creative Commons License
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
Veterinary Sciences | 2.4 | 2.2 | 2.2 | 2.2 | 1 | 1.091 | 2022 | Q1 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
Veterinary Sciences | 2.4 | 2.2 | 2.2 | 2.2 | 1 | 1.091 | 2022 | Q1 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Veterinary Sciences | 2.3 | 0.885 | 0.524 | 2022 | Q2 |