High concordance rates of premalignant gastric lessions assessed by OLGA and OLGIM in monozygotic and dyzigotic twins

Abstract

Background: The development and progression of chronic H. pylori gastritis toward pre- neoplastic gastric lesions is a multifactorial process. To date, there are no studies that would evaluate the role of shared genetic influences on susceptibility and phenotype of chronic H. pylori gastritis and premalignant gastric alterations in twins. Aims: To compare histological alterations of gastric mucosa according to Sydney classification, OLGA and OLGIM staging systems in monozygotic and dizygotic twins. Methods: This prospective study included 13 pairs of monozygotic and 16 pairs of dizygotic twins aged >18 years. At endoscopy five gastric biopsy specimens were collected according Sydney System protocol. H. pylori gastritis was assessed by histology and graded by OLGA and OLGIM staging systems. Results: Concordance rate for chronic H. pylori gastritis in monozygotic twins was 69.2% and in dizygotic twins 62.5%, P > 0.05. Concordance for antrum athrophy in monozygotic twins was 76.9% and 75% in dizygotic twins (P > 0.05). Concordance for corpus athrophy in monozygotic twins was 92.3% and in dizygotic twins 87.5% (P > 0.05). Concordance for antrum IM in monozygotic twins was 84.6% and in dizygotic 75% (P > 0.05). Concordance for corpus IM in monozygotic twins was 84.6% and in dizygotic 93.7% (P > 0.05). There was no statistical difference in concordance rates for OLGA and OL