Options
Modelling and Biopharmaceutical Evaluation of O
Date Issued |
---|
2022-05-06 |
Abstracts. Scientists section
ISBN 978-9955-15-749-6
Introduction: Topical therapy of skin diseases is considered highly challenging due to the low permeability of the active substances into the skin layers. In the present study, pharmaceutical form o/w cream was evaluated as delivery carriers for naftifine hydrochloride. The aim of the study: To formulate stable o/w cream and evaluate its quality. Materials and methods: O/w cream consists of two phases. Each phase is prepared separately. Naftifine HCl is added to the oil phase. The o/w cream is prepared at 80 ℃ temperature. Physicochemical analysis methods were used to evaluate the parameters of formulated o/w cream form with naftifine HCl: pH was determined by pH meter, viscosity was measured by viscometer, the stability of the cream was evaluated by heating – cooling and centrifugation methods; biopharmaceutical studies were performed by using Franz diffusion cells. Quantitative analysis of naftifine HCl was performed using UPLC. Results: Prepared pharmaceutical form of an o/w cream increased naftifine HCl uptake by about 3 fold compared with commercial cream. The increased amount of active substance, reduced the release of naftifine HCl. The formulations of the more viscous creams were characterized by a better release of naftifine HCl. TEA increased the o/w cream pH value. This cream is suitable for use on the skin, and does not cause irritation. Stability studies have shown that all cream formulations were stable. Conclusions: The maximum release was due to the proper viscosity of the cream, and the selection of suitable substances that increased the release of naftifine HCl from the experimental formulations. All o/w cream formulations were stable. o/w cream was suitable for damaged skin, TEA increased the pH value of the creams.