Leucocyte telomere length in patients with laryngeal squamous cell carcinoma : Presentation
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2019-06-29 |
Introduction: Telomeres represent specialized DNA structures located at the ends of chromosomes. These structures are essential for chromosome integrity and genomic stability. Meta-analysis revealed that the short telomeres were related with increased cancer risk. However, there are studies which data are controversial. Study aim: To evaluate the associations between telomere length in leucocytes and development of laryngeal squamous cell carcinoma (LSCC). Material & Methods: This case-control study consisted of 105 histologically verified LSCC patients (stage from I to IV) and 186 healthy subjects as a reference group. DNA samples of the represented population were extracted from peripheral venous blood. Telomere length was measured by the real-time polymerase chain reaction method. Statistical analysis was performed using „IBM SPSS Statistics 20.0“. Results: The mean age of study groups did not differ statistically significantly (median (IQR): 61 (35) in LSCC vs. 58 (25) in control group, p= 0.421). No statistically significant correlations were found between age and leukocyte relative telomere length (RTL). However, statistically significantly longer RTL in LSCC patients comparing to controls (median (IQR): 0.61 (0.41) vs. 0.31 (0.66), p< 0.001) was revealed. LSCC group consisted mostly of male patients. Therefore we compared the RTL only between males from both groups and also find significantly longer RTL in LSCC patients (median (IQR): 0.61 (0.42) vs. 0.35 (0.73), p=0.05). Conclusions: Results of the present study show the possible impact of RTL on LSCC development. However further investigations to clarify our findings are required.