Investigation of cadmium concentration after acute intoxication
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Pav.
Bibliogr.: p. 323 (21 pavad.).
Cadmium is an ubiquitous metal and cumulative poison, which may cause liver and kidney damaging and carcinogenic changes. We investigated the influence of cadmium chloride on the blood, kidney, liver, spleen, heart and skeletal muscle. The experiments were performed on white laboratory mice using intraperitoneal injections of LD50. amount of cadmium chloride solution. Cadmium concentration in rnice blood and in tissue specimens was detected by atomic absorption spectroscopy. Our experiments data revealed that Cd2+ concentration in liver remains high after significant arising during first two hours after injection. It shows that the liver is the primary target organ in acute Cd poisoning. It is the reason why liver suffers from Cd2+ at first and most seriously. Monotonic arising of Cd2+ concentration was found in kidney. So the kidney is also a target organ of cadmium toxicity.