Adipose Tissue-derived Stem Cell Extracellular Vesicles Suppress Glioblastoma Viability, Invasiveness and Angiogenesis

Abstract

Glioblastoma multiforme is the most common malignant type of tumour in central nervous system with medial patient survival of only 14 months within the diagnosis. Despite the possible range of treatment involving surgical resections followed by radio/chemotherapy, no effective therapy has been developed thus far. Recently, stem cell and nanomedicine therapies and have been considered as a possibility. Extracellular vesicles (EVs), a naturally occurring nanoparticles secreted from almost all types of cells, ranging from 30 to 1000 nm in diameter are considered a major players in intracellular communication between proximal cells without direct cell contact. However, should EVs be used as a means of therapy or drug delivery, not only the benefits, but possible complications must be considered. The present study explores the effects of EVs secreted by Adipose-derived mesenchymal stem cells on glioblastoma cells in vitro and in vivo.