A Case report: inflammatory myofibroblastic tumour of the bladder

Abstract

Background The inflammatory myofibroblastic tumour is known since 1939 and significant knowledge about it has been generated during the last few decades. Unfortunately, more than eight decades later we are still incapable to answer questions regarding the pathophysiology and aetiology of this condition as well as to understand the possible behaviour of these tumours. All the cases of inflammatory myofibroblastic tumours should be recognised thoroughly because of the importance to accumulate knowledge and experience regarding diagnostics and treatment of these cases. Case Report A 54-year-old male who has not been previously diagnosed with any illnesses was consulted for haematuria. A bladder tumour was suspected after ultrasound examination which showed papillary masses in the bladder. Pelvic computed tomography showed 6 x 5 cm homogenous mass in the anterior wall of the bladder with clear margins and wall infiltration. The patient was hospitalized for transurethral tumour biopsy to clarify the diagnosis and to decide whether the systematic neoadjuvant treatment is necessary. Histopathological analysis confirmed the diagnosis of inflammatory myofibroblastic tumour spreading in the urothelial stroma and ALK (2p23) rearrangement was also confirmed with the molecular FISH technique. It was decided to perform a open partial cystectomy. The patient has completely recovered. A follow-up plan is scheduled for six months. Conclusions Knowledge about the inflammatory myofibroblastic tumour was firmly expanded during the last few decades. Single case reports must be recognized, and larger-scale research should be initiated particularly to build awareness of the existence of such lesions, as well as the education of medical staff which should make a significant change in expanding perception of IMT and management of new cases.