SFlt-1, PlGF and their ratio in different manifestations of preeclampsia

Abstract

Objective: We investigated sFlt-1, PlGF and their ratio variation in different manifestations of preeclampsia, correlation with uterine blood flow, blood pressure, proteinuria and liver enzymes. Materials and methods: Study included 46 patients with different manifestations of preeclampsia treated in Kaunas University Clinics during the period of 01 06 2011- 01 12 2011 and 46 controls with normal pregnancy. SFlt-1, PlGF concentrations and SFlt-1/PlGF ratio was compared in cases of preeclampsia to 46 controls, then the same variables were compared in cases of early- onset versus late-onset and between severe versus mild preeclampsia. Also the angiogenic factors correlation to uterine blood flow, proteinuria, blood pressure and liver enzymes was investigated. Results: SFlt-1 concentration, sFlt-1/PlGF ratio was significantly higher and PlGF concentration lower in preeclamptic patients compared to controls (p<0.0001), as well as in cases of early- onset ( n=17) compared to late- onset (n=29) preeclampsia (p<0.001, p<0.0001 and PlGF ), and in the cases of severe (n=26) preeclampsia compared to mild(n=20) preeclampsia (p<0.008, p<0.002 and p<0.027). SFlt-1 correlated significantly with proteinuria (p<0,001, r=0,5) and GOT (p<0.013, r=0.4). PlGF correlated with maximal systolic blood pressure (p<0.014, r=-0.3) and GPT (p<0,029, r=-0.36). Conclusions: SFlt-1concentration, sFlt-1/PlGF ratio was significantly elevated and PlGF concentration significantly lower in cases of preeclampsia, compared to normal pregnancies as well as in cases of severe and early onset preeclampsia compared to mild and late preeclampsia . SFlt-1 concentration correlated significantly with proteinuria and GOT, while PlGF concentration correlated with maximal systolic.