Comparative Analysis of Single-Component Excipients and Substances with Amelanchier alnifolia l. Fruits Extract

Abstract

Background. Saskatoon berry (Amelanchier alnifolia L.) is deciduous shrub, that are found in forests or thickets. Fruits: small, black-blue berries, accumulating flavanoids, phenolic compounds and anthocyanins. Due to its composition, particularly rich in bioactive compounds, especially polyphenols, the Saskatoon berry has the potential to act as a highly beneficial antioxidant, anti-inflammatory, antitumor, hypoglycemic, antidiabetic, and antiradical agent. Additionally, it can regulate glucose levels and glycogen accumulation in the human diet, showcasing significant nutritional and nutraceutical value [1]. Aim. The aim of this study was to compare the properties of powders and powders with Amelanchier alnifolia L. fruits extract. Methods. The berries were sampled from Rietavas district in 2023 July. The best ultrasonic extraction results were obtained with freeze – drying berries at 30% ethanol concentration. Powders containing Amelanchier alnifolia L. extract are manufactured using liquid/solid technology. Selected excipients: microcrystalline cellulose, lactose monohydrate and magnesium aluminium metasilicate (Neusilin ® US2). Comparison of powder moisture content, powder flowability, angle of repose, and tap density. Results. Results showed significant differences on the powders. The best results were obtained in determining the moisture content of lactose monohydrate and Amelanchier alnifolia L. powders (1,36%). The best results for the flowability (1,097 g/s) and cone angle (27˚) of powders were obtained for lactose monohydrate and Amelanchier alnifolia L. powders. The best tap density was determined for magnesium aluminum metasilicate (Neusilin ® US2) powder (0,156 g/ml). The highest moisture content was found in magnesium aluminum metasilicate (Neusilin ® US2) powders (10,33%). The largest cone angle (52˚) was in magnesium aluminum metasilicate (Neusilin ® US2) powders. The worst flowability (1,765 g/s) were found in microcrystalline cellulose and Saskatoon berry powders. Lactose monohydrate powders had the lowest tap density (0,833 g/ml). Conclusion. After evaluating the quality of the powder, it was determined that the best properties were achieved with lactose monohydrate and Amelanchier alnifolia L. powders.