Adipocytokines, incretins, insulin resistance and body composition coherence in women with previously diagnosed gestational diabetes mellitus

Abstract

Introduction Adipose tissue is a major source of adipocytokines. It plays an important role for the development of insulin resistance (IR). Data implicate that incretins enhance insulin sensitivity. One aspect of the pathophysiology of gestational diabetes (GDM) is IR. The relationship between adipocytokines, incretins and GDM might be closely associated. Aim To evaluate the coherence of adipocytokines (adiponectin and leptin), incretins (GLP-1, GIP), insulin resistance and BMI in women with previously diagnosed GDM. Methods We examined 126 women with previously (16–43 years ago) diagnosed GDM. BMI, incretins, adipocytokines were evaluated. IR was calculated with HOMAIR index. Data expressed as meanGS.D. for parametric data or median (min–max) for non-parametric data. ANOVA was used to compare data between groups of three or more variables. Non-parametric data correlation analysis was performed using the Spearman’s correlation coefficient. The results were considered statistically significant at P!0.05. Results Women’s average age was 53.52G8.34 years (39–77 years). The coherence between adipocytokines, incretins and BMI was observed: increased BMI determined decreased adiponectin (rZK0.361, P!0.01), and increased leptin (rZ0.838, P!0.01) either incretins concentrations (GIP rZ0.270, PZ0.01 and GLP-1 rZ0.167, PZ0.21). HOMA-IR was higher in obese women (rZ0.641, P!0.01). Data analysed in different BMI categories (normal weight/overweight/ obese): adiponectin (26.8(12.2–76.8)/21.4 (10.8–54.4)/17.9 (5.2–41.6), P!0.01), leptin (5.9(0.2–16.1)/12.5(3.8–122.1)/24.7(11.1–74.9), P!0.01), GIP (0.8(0.2– 2.9)/0.97(0.2–5.2)/1.29(0.2–18.2), PZ0.145), GLP-1 (0.06(0.04–21.7) /0.06(0.04–6.1)/0.06(0.04–18.2), PZ0.517), HOMA-IR (2.2(0.5–4.7)/2.5(0.4– 6.4)/4.6(1.2–27.2), P!0.01). No significance between adiponectin and GIP, GLP-1 was defined (rZK0.152, PZ0.156/rZ0.02, PZ0.824). Women with l[...].