Contraversal findings on brain MRI MTA scale in radiologist and neurologist assessment in Lithuanian demented patients
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no. ADPD7-0251
B04.h. Imaging, Biomarkers, Diagnostics: CSF, blood, body fluid biomarkers.
ISBN 978-3-318-05023-3
Aims The aim of study was to compare subjective visual assessment and linear measurement results of MTA found by radiologist and neurologist separately using MRI modality in Alzheimer (AD) and other dementia patients, to compare results of different specialists and evaluate the relation between MTA score and biomarkers levels in AD patients. Method Subjective and linear MTA assessment on brain MRI images of 43 patients were performed separately by radiologist and neurologist. Cognitive decline was assessed by MMSE. Aβ42, t-tau, p-tau CSF concentrations were measured in AD patients. Results There were 23 AD patients (mean age 69,13±7,8 yrs, mean MMSE 20,87±2,54 pts) and 20 other dementia patients (mean age 58,15±6,88 yrs, mean MMSE 20,3± 4,6pts). The most common subjective MTA score according to neurologist and radiologist was 2 in both groups. Though results differed significantly between assessment made by radiologist and neurologist using both types of measurements, most of the linear measurement values correlated strongly between both specialists. There was no difference comparing linear measurements between dementia groups. Subjective MTA score was lower in other dementia group vs AD patients according to both specialists. Most of linear measurements done by neurologist correlated with p-tau while radiologist’s measurements correlated with t–tau in CSF moderately. Conclusion Subjective evaluation was similar in both specialists and it may be considered that neurologist could use MTA system in daily practice. Other dementia patients had lower MTA scores but still MTA scale could not be used as differential diagnostic tool alone according to results.