Neuromarkers for in-hospital mortality prediction. Are they valuable?
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2016-05-28 |
Background and Goal of Study: Traumatic brain injury (TBI) is serious and of ten lethal condition so predicting its outcomes can be really beneficial. Investigation of neuromarkers is simple but not widely used method. The aim of this study was to compare S100B and NSE values for in-hospital mortality prediction af ter TBI. Materials and methods: A prospective study took place in Anesthesiology clinic of Lithuanian University of Health Sciences Kaunas Clinics. Serum of 46 patients with severe TBI was investigated for neuromarkers S100B and NSE at hospital admission and 24, 48 and 72 hours af ter the admission. Outcomes were assessed and compared to specific values using nonparametric statistical tests. All 4 measurements were obligatory for inclusion to the study. Level of p≤0.05 was assumed as statistically significant. Approval of Regional bioethics committee was obtained before study initiation. Results: 46 patients were involved in the study. The average age was 55.33±16.8 years and there was no significant dif ference between women and men, however the number of men were higher than women, 35 and 11 respectively. The median of each test was used to evaluate if the specific value had an impact on in-hospital mortality. The medians of S100B were 14.98 pg/ ml [7.21; 67.66], 12.69 pg/ml [7.21; 66.88], 10.3 pg/ml [7.21; 40.77] and 9.7 pg/ml [0.9; 12.69] at hospital admission, af ter 24, 48 and 72 hours respectively. Only 12.69 pg/ml and 10.3 pg/ml dif fered significantly but had no impact on increasing the risk of in-hospital mortality. The medians of NSE were 9.72 μg/l [3.93; 21.54], 7.56 μg/l [3.99; 14.65], 6.24 μg/l [3.15; 17.23], 5.65 μg/l [3.08; 15.87] at hospital admission, af ter 24, 48 and 72 hours respectively. The values of 7.56 μg/l and 6.24 μg/l had a significant dif ference and increased the risk of in-hospital mortality 4.0 and 9.35 times respectively. The measurement of both neuromarkers at hospital admission and af ter 72 hours had n