Comparison of the expression of Ki-67 marker in ameloblastoma and odontogenic keratocyst: a systematic literature review

Abstract

Introduction The development and progression of odontogenic cysts and tumors are associated with incorrect adhesion of molecules, proliferation of cells, angiogenesis and osteolysis [1]. Ki- 67 is a proliferation marker (nuclear non-histone protein) used in the diagnosis and prognosis of pathological lesions, mainly in human tumors [2]. This marker helps to assess the aggressive potential of lesions, mostly by measuring cell proliferation index (PI) [3]. Ki- 67 marker differences of proliferative activity in odontogenic keratocyst and ameloblastoma are considered, because it could play a role in biological aggressive behavior [4]. Aim The aim of this study is to compare the proliferation index in ameloblastoma and odontogenic keratocyst in order to find out which lesion has a higher potential for aggression. Methods A systematic search was conducted in five electronic databases, including Pubmed, Wiley Online, Cochrane Library and ScienceDirect. The protocol of the study was conducted in line with the PRISMA statement. Combinations including keywords „ameloblastoma“, „odontogenic tumor“, „odontogenic keratocyst“, „immunohistochemical markers” were used. According to the PICOS schema, the study included prospective trials (S) in which adult patients diagnosed with ameloblastoma or odontogenic keratocyst (P), which immunohistochemical expression of Ki-67 were investigated (I) in different lesions (C) in order to evaluated the aggressive potential of lesions (O). The criteria for the study inclusion were full-text studies published in English, clinical studies with humans. […].